Modulation of the neurotransmitter release in rat cerebellar neurons by GROβ

被引：69

作者：

Ragozzino, D

Giovannelli, A

Mileo, AN

Limatola, C

Santoni, A

Eusebi, F

机构：

[1] Univ Rome La Sapienza, Dipartimento Med Sperimentale & Patol, I-00158 Rome, Italy

[2] Univ Aquila, Dipartimento Med Sperimentale, I-00158 Rome, Italy

[3] Ist Regina Elena, Ctr Ric Sperimentale, Lab Biofis, I-00158 Rome, Italy

来源：

NEUROREPORT | 1998年 / 9卷 / 16期

关键词：

cerebellar excitatory post synaptic currents; cerebellar granules; cerebellar slices; chemokines; extra cellular signal-regulated kinases;

D O I：

10.1097/00001756-199811160-00011

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

WE report here that, in cultured cerebellar granule cells, the CXC chemokine GRO beta stimulates the signaling pathway of the extracellular signal-regulated kinases, and enhances both evoked and spontaneous postsynaptic currents in patch clamped Purkinje neurons from rat cerebellar slices. The GRO beta-induced enhancement of the excitatory post-synaptic currents evoked by stimulating the parallel fibres is blocked by the inhibitor of the extracellular signal-regulated kinases pathway PD98059, which also reduces both basal frequency of spontaneous post-synaptic currents and mean amplitude of evoked excitatory post-synaptic currents. Our results suggest that GRO beta modulates neurotransmitter release in the cerebellum through the activation of the extracellular signal-regulated kinases pathway. NeuroReport 9: 3601-3606 (C) 1998 Lippincott Williams & Wilkins.

引用

页码：3601 / 3606

页数：6

共 25 条

[1] Brain-derived neurotrophic factor blocks long-term depression in rat visual cortex [J].