Diversification of human plasmacytoid predendritic cells in response to a single stimulus

被引：122

作者：

Alculumbre, Solana G. ^{[1
,2
]}

Saint-Andre, Violaine ^{[1
,3
]}

Di Domizio, Jeremy ^{[4
]}

Vargas, Pablo ^{[1
,5
]}

Sirven, Philemon ^{[1
,2
]}

Bost, Pierre ^{[1
,2
,6
]}

Maurin, Mathieu ^{[1
,2
]}

Maiuri, Paolo ^{[1
,7
]}

Wery, Maxime ^{[1
,3
]}

San Roman, Mabel ^{[1
,2
]}

Savey, Lea ^{[8
,9
,10
]}

Touzot, Maxime ^{[11
]}

Terrier, Benjamin ^{[12
]}

Saadoun, David ^{[8
,9
,10
]}

Conrad, Curdin ^{[4
]}

Gilliet, Michel ^{[4
]}

Morillon, Antonin ^{[1
,3
]}

Soumelis, Vassili ^{[1
,2
,13
]}

机构：

[1] PSL Res Univ, Inst Curie, Ctr Rech, Paris, France

[2] INSERM, Immun & Canc, U932, Paris, France

[3] Univ Paris 06, CNRS UMR 3244, ncRNA Epigenet & Genome Fluid, Paris, France

[4] Univ Hosp CHUV, Dept Dermatol, Lausanne, Switzerland

[5] CNRS UMR144, Paris, France

[6] PSL Res Univ, Dept Biol, Ecole Normale Super, Paris, France

[7] IFOM Fdn, Inst FIRC Mol Oncol, Milan, Italy

[8] UPMC Univ Paris, Sorbonne Univ, UMR7211, Paris, France

[9] UPMC Univ Paris, Sorbonne Univ, Inflammat Immunopathol Biotherapy Dept DHU i2B, Paris, France

[10] Grp Hosp Pitie Salpetriere, AP HP, Dept Internal Med & Clin Immunol, Natl Reference Ctr Autoimmune & System Dis, Paris, France

[11] AURA Paris Plaisance, Paris, France

[12] Univ Paris 05, Cochin Hosp, AP HP, Dept Internal Med,Natl Referral Ctr Rare Autoimmm, Paris, France

[13] CIC IGR Curie 1428, Paris, France

来源：

NATURE IMMUNOLOGY | 2018年 / 19卷 / 01期

关键词：

INTERFERON-PRODUCING CELLS; LONG NONCODING RNAS; DENDRITIC CELLS; CUTTING EDGE; I INTERFERON; T-CELLS; DIFFERENTIATION; ACTIVATION; EXPRESSION; INNATE;

D O I：

10.1038/s41590-017-0012-z

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Innate immune cells adjust to microbial and inflammatory stimuli through a process termed environmental plasticity, which links a given individual stimulus to a unique activated state. Here, we report that activation of human plasmacytoid predendritic cells (pDCs) with a single microbial or cytokine stimulus triggers cell diversification into three stable subpopulations (P1-P3). P1-pDCs (PD-L1(+)CD80(-)) displayed a plasmacytoid morphology and specialization for type I interferon production. P3-pDCs (PD-L1-CD80(+)) adopted a dendritic morphology and adaptive immune functions. P2-pDCs (PD-L1(+)CD80(+)) displayed both innate and adaptive functions. Each subpopulation expressed a specific coding-and long-noncoding-RNA signature and was stable after secondary stimulation. P1-pDCs were detected in samples from patients with lupus or psoriasis. pDC diversification was independent of cell divisions or preexisting heterogeneity within steady-state pDCs but was controlled by a TNF autocrine and/or paracrine communication loop. Our findings reveal a novel mechanism for diversity and division of labor in innate immune cells.

引用

页码：63 / +

页数：15

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