Lithium perchlorate-accelerated Baylis-Hillman reactions

被引：121

作者：

Kawamura, M

Kobayashi, S ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, CREST, Japan Sci & Technol Corp,Bunkyo Ku, Tokyo 1130033, Japan

[2] Tokyo Univ Sci, Fac Sci, Dept Appl Chem, Shinjuku Ku, Tokyo 1620825, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 08期

关键词：

D O I：

10.1016/S0040-4039(98)02705-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The coupling of alpha,beta-unsaturated carbonyl compounds with aldehydes (the Baylis-Hillman reaction) was accelerated in the presence of a catalytic amount of 1,4-diazabicyclo[2,2,2]octane (DABCO) and lithium perchlorate in ether. A preliminary kinetic study revealed that the relative rate of the reaction using LiClO4 in ether was 8.0 x 10(2) times faster than that of the reaction without LiClO4. (C) 1999 Elsevier Science Ltd.

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页码：1539 / 1542

页数：4

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