Synthesis and anthelmintic properties of arylquinolines with activity against drug-resistant nematodes

被引：95

作者：

Rossiter, S

Péron, JM

Whitfield, PJ

Jones, K

机构：

[1] Kings Coll London, Dept Chem, London WC2R 2LS, England

[2] Kingston Univ, Sch Chem & Pharmaceut Sci, Kingston upon Thames KT1 2EE, Surrey, England

[3] Kings Coll London, Div Life Sci, London SE1 9NN, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 21期

基金：

英国惠康基金;

关键词：

quinolines; Suzuki coupling; anthelmintics;

D O I：

10.1016/j.bmcl.2005.07.044

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

2,4-Disubstituted quinolines with additional substituents in positions 5-8 have been found to have anthelmintic properties. A number of 2,4-dimethoxy-6- or 8-arylquinolines have potent activity against the sheep nematode Haemonchus contortus, with LD99 values of the same order of magnitude as levamisole. These arylquinolines maintain their activity against levamisole-, ivermectin- and thiabendazole-resistant strains of H. contortus. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：4806 / 4808

页数：3

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