Serum leptin concentrations and satiety in Parkinson's disease patients with and without weight loss

被引：43

作者：

Evidente, VGH

Caviness, JN

Adler, CH

Gwinn-Hardy, KA

Pratley, RE

机构：

[1] Mayo Clin Scottsdale, Dept Neurol, Scottsdale, AZ 85259 USA

[2] Mayo Clin Jacksonville, Jacksonville, FL 32224 USA

[3] Natl Inst Hlth, Phoenix, AZ USA

来源：

MOVEMENT DISORDERS | 2001年 / 16卷 / 05期

关键词：

Parkinson's disease; leptin; satiety; weight loss;

D O I：

10.1002/mds.1165

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We compared serum leptin and satiety measures in 18 Parkinson's disease (PD) patients with unintended weight loss (WL) and 18 PD patients whose weight was stable (WS). Mean serum leptin concentrations tended to be lower in WL than WS patients, but this did not reach statistical significance. Body mass index correlated with serum leptin concentrations. Ratings of hunger. satiety, fullness, and thirst did not differ between groups. However. the mean sensation of fullness before meals correlated with serum leptin in the entire cohort of patients, particularly in the WL group. ne results indicate that unintended weight loss in PD patients is unlikely to be due to abnormal serum leptin concentrations. (C) 2001 Movement Disorder Society.

引用

收藏

页码：924 / 927

页数：4

相关论文

共 16 条

[1]

BRABANT G, 1996, ENDOC SOC, P11

[2] Cerebrospinal fluid and plasma leptin measurements: Covariability with dopamine and cortisol in fasting humans [J].

Hagan, MM ;

Havel, PJ ;

Seeley, RJ ;

Woods, SC ;

Ekhator, NN ;

Baker, DG ;

Hill, KK ;

Wortman, MD ;

Miller, AH ;

Gingerich, RL ;

Geracioti, TD .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1999, 84 (10) :3579-3585

[3] Leptin levels in patients with anorexia nervosa are reduced in the acute stage and elevated upon short-term weight restoration [J].

Hebebrand, J ;

Blum, WF ;

Barth, N ;

Coners, H ;

Englaro, P ;

Juul, A ;

Ziegler, A ;

Warnke, A ;

Rascher, W ;

Remschmidt, H .

MOLECULAR PSYCHIATRY, 1997, 2 (04) :330-334

[4] LEWY BODIES IN THE LATERAL HYPOTHALAMUS - DO THEY IMPLY NEURONAL LOSS [J].

KREMER, HPH ;

BOTS, GTAM .

MOVEMENT DISORDERS, 1993, 8 (03) :315-320

[5] LEPTIN LEVELS IN HUMAN AND RODENT - MEASUREMENT OF PLASMA LEPTIN AND OB RNA IN OBESE AND WEIGHT-REDUCED SUBJECTS [J].

MAFFEI, M ;

HALAAS, J ;

RAVUSSIN, E ;

PRATLEY, RE ;

LEE, GH ;

ZHANG, Y ;

FEI, H ;

KIM, S ;

LALLONE, R ;

RANGANATHAN, S ;

KERN, PA ;

FRIEDMAN, JM .

NATURE MEDICINE, 1995, 1 (11) :1155-1161

[6] Cerebrospinal fluid leptin in anorexia nervosa: Correlation with nutritional status and potential role in resistance to weight gain [J].

Mantzoros, C ;

Flier, JS ;

Lesem, MD ;

Brewerton, TD ;

Jimerson, DC .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1997, 82 (06) :1845-1851

[7] The role of leptin in human obesity and disease: A review of current evidence [J].

Mantzoros, CS .

ANNALS OF INTERNAL MEDICINE, 1999, 130 (08) :671-680

[8] INCREASED PREVALENCE OF UNDERNUTRITION IN PARKINSONS-DISEASE AND ITS RELATIONSHIP TO CLINICAL-DISEASE PARAMETERS [J].

MARKUS, HS ;

TOMKINS, AM ;

STERN, GM .

JOURNAL OF NEURAL TRANSMISSION-PARKINSONS DISEASE AND DEMENTIA SECTION, 1993, 5 (02) :117-125

[9] The possible role of prolactin in the circadian rhythm of leptin secretion in male rats [J].

Mastronardi, CA ;

Walczewska, A ;

Yu, WH ;

Karanth, S ;

Parlow, AF ;

McCann, SM .

PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, 2000, 224 (03) :152-158

[10]

OTAKE K, 1980, AM J GASTROENTEROL, V74, P157