Which way does the Wnt blow? Exploring the duality of canonical Wnt signaling on cellular aging

被引：42

作者：

DeCarolis, Nathan A. ^{[1
]}

Wharton, Keith A., Jr. ^{[2
,3
]}

Eisch, Amelia J. ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Psychiat, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Mol Biol, Dallas, TX USA

[3] Univ Texas SW Med Ctr Dallas, Dept Pathol, Dallas, TX USA

来源：

BIOESSAYS | 2008年 / 30卷 / 02期

关键词：

D O I：

10.1002/bies.20709

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Critical cellular functions, including stem cell maintenance, fate determination, and cellular behavior, are governed by canonical Wnt signaling, an evolutionarily conserved pathway whose intracellular signal is transduced by beta-catentin. Emerging evidence suggests that canonical Wnt signaling influences cellular aging, indicating that increases in Wnt signaling delay age-related deficits.((1)) However, recent Science papers suggest that Wnt signaling accelerates the onset of aging.((2,3)) In an attempt to resolve this paradox and clarify how Wnt signaling affects aging, we provide a selective review of research relevant to Wnt signaling and aging.

引用

页码：102 / 106

页数：5

共 43 条

[1] Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting β-catenin from T cell factor- to Forkhead box O-mediated transcription [J].

Almeida, Maria ;

Han, Li ;

Martin-Millan, Marta ;

O'Brien, Charles A. ;

Manolagas, Stavros C. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (37) :27298-27305

[2] Wnt-3a overcomes β-amyloid toxicity in rat hippocampal neurons [J].

Alvarez, AR ;

Godoy, JA ;

Mullendorff, K ;

Olivares, GH ;

Bronfman, M ;

Inestrosa, NC .

EXPERIMENTAL CELL RESEARCH, 2004, 297 (01) :186-196

[3] Age-associated shifts in cardiac gene transcription and transcriptional responses to ischemic stress [J].

Ashton, KJ ;

Willems, L ;

Holmgren, K ;

Ferreira, L ;

Headrick, JP .

EXPERIMENTAL GERONTOLOGY, 2006, 41 (02) :189-204

[4] GSK3α exhibits β-catenin and tau directed kinase activities that are modulated by Wnt [J].

Asuni, Ayodeji A. ;

Hooper, Claudie ;

Reynolds, C. Hugh ;

Lovestone, Simon ;

Anderton, Brian H. ;

Killick, Richard .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2006, 24 (12) :3387-3392

[5] Ageing - Balancing regeneration and cancer [J].

Beausejour, Christian M. ;

Campisi, Judith .

NATURE, 2006, 443 (7110) :404-405

[6] Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis [J].

Brack, Andrew S. ;

Conboy, Michael J. ;

Roy, Sudeep ;

Lee, Mark ;

Kuo, Calvin J. ;

Keller, Charles ;

Rando, Thomas A. .

SCIENCE, 2007, 317 (5839) :807-810

[7] Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase [J].

Brunet, A ;

Sweeney, LB ;

Sturgill, JF ;

Chua, KF ;

Greer, PL ;

Lin, YX ;

Tran, H ;

Ross, SE ;

Mostoslavsky, R ;

Cohen, HY ;

Hu, LS ;

Cheng, HL ;

Jedrychowski, MP ;

Gygi, SP ;

Sinclair, DA ;

Alt, FW ;

Greenberg, ME .

SCIENCE, 2004, 303 (5666) :2011-2015

[8] Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors [J].

Campisi, J .

CELL, 2005, 120 (04) :513-522

[9] Beta-catenin signaling plays a disparate role in different phases of fracture repair: Implications for therapy to improve bone healing [J].

Chen, Yan ;

Whetstone, Heather C. ;

Lin, Alvin C. ;

Nadesan, Puviindran ;

Wei, Qingxia ;

Poon, Raymond ;

Alman, Benjamin A. .

PLOS MEDICINE, 2007, 4 (07) :1216-1229

[10] Aberrant Wnt/β-catenin pathway activation in idiopathic pulmonary fibrosis [J].

Chilosi, M ;

Poletti, V ;

Zamò, A ;

Lestani, M ;

Montagna, L ;

Piccoli, P ;

Pedron, S ;

Bertaso, M ;

Scarpa, A ;

Murer, B ;

Cancellieri, A ;

Maestro, R ;

Semenzato, G ;

Doglioni, C .

AMERICAN JOURNAL OF PATHOLOGY, 2003, 162 (05) :1495-1502

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