Capturing pluripotency

被引：357

作者：

Silva, Jose ^{[1
,2
]}

Smith, Austin ^{[1
,2
]}

机构：

[1] Univ Cambridge, Wellcome Trust Ctr Stem Cell Res, Cambridge CB2 1QR, England

[2] Univ Cambridge, Dept Biochem, Cambridge CB2 1QR, England

来源：

CELL | 2008年 / 132卷 / 04期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1016/j.cell.2008.02.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this Essay, we argue that pluripotent epiblast founder cells in the embryo and embryonic stem (ES) cells in culture represent the ground state for a mammalian cell, signified by freedom from developmental specification or epigenetic restriction and capacity for autonomous self-replication. We speculate that cell-to-cell variation may be integral to the ES cell condition, safe-guarding self-renewal while continually presenting opportunities for lineage specification.

引用

收藏

页码：532 / 536

页数：5

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