Enantioselective synthesis of (+)-trypargine and (+)-crispine E

被引：32

作者：

Czarnocki, Stefan J. ^{[1
]}

Wojtasiewicz, Krystyna ^{[1
]}

Jozwiak, Adam P. ^{[1
]}

Maurin, Jan K. ^{[2
,3
]}

Czarnocki, Zbigniew ^{[1
]}

Drabowicz, Jozef ^{[4
]}

机构：

[1] Warsaw Univ, Fac Chem, PL-02093 Warsaw, Poland

[2] Natl Med Inst, PL-00750 Warsaw, Poland

[3] Inst Atom Energy, PL-05400 Otwock, Poland

[4] Polish Acad Sci, Ctr Mol & Macromol Studies, Dept Heteroorgan Chem, PL-90363 Lodz, Poland

来源：

TETRAHEDRON | 2008年 / 64卷 / 14期

关键词：

D O I：

10.1016/j.tet.2008.01.088

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Asymmetric transfer hydrogenation was used as a key step in the synthesis of two guanidine-derived alkaloids (+)-trypargine and (+)-crispine E. The enantiomeric compositions of key intermediates were established on the basis of H-1 NMR spectra with chiral solvating agents. The absolute stereochemistry was proven by X-ray crystallography. (c) 2008 Elsevier Ltd. All rights reserved.

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页码：3176 / 3182

页数：7

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