Lewy body-type degeneration in cardiac plexus in Parkinson's and incidental Lewy body diseases

被引：214

作者：

Iwanaga, K

Wakabayashi, K

Yoshimoto, M

Tomita, I

Satoh, H

Takashima, H

Satoh, A

Seto, M

Tsujihata, M

Takahashi, H

机构：

[1] Nagasaki Kita Hosp, Div Neurol, Nagasaki 8528061, Japan

[2] Niigata Univ, Brain Res Inst, Brain Dis Res Ctr, Niigata 951, Japan

[3] Niigata Univ, Brain Res Inst, Dept Pathol, Niigata 951, Japan

[4] Taisho Pharmaceut Co Ltd, Med Res Labs, Ohmiya, Japan

来源：

NEUROLOGY | 1999年 / 52卷 / 06期

关键词：

D O I：

10.1212/WNL.52.6.1269

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Heart tissues of patients with PD or incidental Lewy body (LB) disease (ILBD) were examined by light and electron microscopy. LBs and alpha-synuclein-positive neurites were identified in the hearts from 9 of 11 patients with PD and from 7 of 7 patients with ILBD. LBs were present in both tyrosine: hydroxylase-positive and -negative nerve processes, which are nerves of extrinsic sympathetic and intrinsic origin, respectively. These findings provide histologic evidence that the postganglionic sympathetic and intrinsic neurons in the heart are involved in the PD disease process.

引用

页码：1269 / 1271

页数：3

共 10 条

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[Anonymous], HDB PARKINSONS DIS

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