Comparative effects of olive oil-based and soyabean oil-based emulsions on infection rate and leucocyte count in critically ill patients receiving parenteral nutrition

被引:33
作者
Antonio, Javier Mateu-de [1 ]
Grau, Santiago [1 ]
Luque, Sonia [1 ]
Marin-Casino, Monica [1 ]
Albert, Inmaculada [2 ]
Ribes, Esther [1 ]
机构
[1] Hosp Mar, Dept Pharm, Barcelona 08003, Spain
[2] Hosp Mar, Intens Care Unit, Barcelona 08003, Spain
关键词
parenteral nutrition; intravenous fat emulsion; infection; leucocyte count;
D O I
10.1017/S0007114507837433
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Soyabean oil-based emulsions high in linoleic acid used in parenteral nutrition (PN) could interfere with immune function and may increase the risk of septic complications. Olive oil-based emulsions, high in oleic acid, could have fewer immune effects. We compared the effects of a soyabean oil-based emulsion v. an olive oil-based emulsion on infection rate, appearance of new infection episodes, leucocyte count (peak and evolution), acute-phase proteins, and major health outcomes in intensive care unit (ICU) adult patients receiving PN. The study was designed as an observational, retrospective, single-centre, cohort study in a general ICU. Patients in the SOYA cohort (n 16) received a soyabean oil-based emulsion and patients in the OLIVE cohort (n 23), an olive oil-based emulsion. Both cohorts had similar basal characteristics and received a similar energy load. The SOYA cohort received an oleic acid:linoleic acid ratio of 0.43 and the OLIVE cohort 2.99 (P<0.001). No differences were observed in infection rate and appearance, acute-phase proteins, and major health outcomes. At the end of PN, blood leucocyte count decreased by 3.25 x 10(9) cells/l in the SOYA cohort and increased by 4.51 x 10(9) cells/l in the OLIVE cohort from baseline values (P=0.036). Peak leucocyte count presented a trend for a higher value in the OLIVE cohort v. the SOYA cohort (18.86 v. 15.28 x 10(9) cells/l; P=0078). The use of an olive oil-based emulsion in PN had no effect on infection, acute-phase proteins, major health outcomes, and presented higher leucocyte count at the end of PN and a trend to higher peak leucocyte count when compared with soyabean oil-based emulsion in ICU patients.
引用
收藏
页码:846 / 854
页数:9
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