Treatment of metastatic melanoma with autologous CD4+T cells against NY-ESO-1

被引：734

作者：

Hunder, Naomi N. ^{[1
]}

Wallen, Herschel ^{[1
]}

Cao, Jianhong ^{[1
]}

Hendricks, Deborah W. ^{[1
]}

Reilly, John Z. ^{[1
]}

Rodmyre, Rebecca ^{[1
]}

Jungbluth, Achim ^{[3
]}

Gnjatic, Sacha ^{[3
]}

Thompson, John A. ^{[2
]}

Yee, Cassian ^{[1
,2
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA

[2] Univ Washington, Seattle, WA 98195 USA

[3] Mem Sloan Kettering Canc Ctr, Ludwig Inst Canc Res New York Branch, New York, NY 10021 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2008年 / 358卷 / 25期

关键词：

D O I：

10.1056/NEJMoa0800251

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We developed an in vitro method for isolating and expanding autologous CD4+ T-cell clones with specificity for the melanoma-associated antigen NY-ESO-1. We infused these cells into a patient with refractory metastatic melanoma who had not undergone any previous conditioning or cytokine treatment. We show that the transferred CD4+ T cells mediated a durable clinical remission and led to endogenous responses against melanoma antigens other than NY-ESO-1.

引用

页码：2698 / 2703

页数：6

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