Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury

被引：413

作者：

Hayashida, Kentaro ^{[2
]}

Sano, Motoaki ^{[1
,4
]}

Ohsawa, Ikuroh ^{[5
]}

Shinmura, Ken ^{[3
]}

Tamaki, Kayoko ^{[3
]}

Kimura, Kensuke ^{[2
]}

Endo, Jin ^{[2
]}

Katayama, Takaharu ^{[2
]}

Kawamura, Akio ^{[2
]}

Kohsaka, Shun ^{[2
]}

Makino, Shinji ^{[1
]}

Ohta, Shigeo

Ogawa, Satoshi ^{[2
]}

Fukuda, Keiichi ^{[1
]}

机构：

[1] Keio Univ, Sch Med, Dept Regenerat Med & Adv Cardiac Therapeut, Shinjuku Ku, Tokyo 1608582, Japan

[2] Keio Univ, Sch Med, Div Cardiol, Tokyo 1608582, Japan

[3] Keio Univ, Sch Med, Dept Internal Med, Div Geriatr Med, Tokyo 1608582, Japan

[4] Japan Sci & Technol Agcy, Precursory Res Embryon Sci & Technol PRESTO, Kawaguchi, Saitama 3320012, Japan

[5] Nippon Med Sch, Grad Sch Med, Inst Dev & Aging Sci, Ctr Mol Hydrogen Med,Dept Biochem & Cell Biol, Kawasaki, Kanagawa 2118533, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2008年 / 373卷 / 01期

关键词：

ischemia-reperfusion injury; anti-oxidant; myocardial infarction; H-2;

D O I：

10.1016/j.bbrc.2008.05.165

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inhalation of hydrogen (H-2) gas has been demonstrated to limit the infarct volume of brain and liver by reducing ischemia-reperfusion injury in rodents. When translated into clinical practice, this therapy must be most frequently applied in the treatment of patients with acute myocardial infarction, since angioplastic recanalization of infarct-related occluded coronary artery is routinely performed. Therefore, we investigate whether H-2 gas confers cardioprotection against ischemia-reperfusion injury in rats. In isolated perfused hearts, H-2 gas enhances the recovery of left ventricular function following anoxia-reoxygenation. Inhaled H-2 gas is rapidly transported and can reach 'at risk' ischemic myocardium before coronary blood flow of the occluded infarct-related artery is reestablished. Inhalation of H-2 gas at incombustible levels during ischemia and reperfusion reduces infarct size without altering hemodynamic parameters, thereby preventing deleterious left ventricular remodeling. Thus, inhalation of H-2 gas is promising strategy to alleviate ischemia-reperfusion injury coincident with recanalization of coronary artery. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：30 / 35

页数：6

共 25 条

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