Cerebral glucose metabolism associated with a fear network in panic disorder

被引：131

作者：

Sakai, Y

Kumano, H

Nishikawa, M

Sakano, Y

Kaiya, H

Imabayashi, E

Ohnishi, T

Matsuda, H

Yasuda, A

Sato, A

Diksic, M

Kuboki, T

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Psychosomat Med, Bunkyo Ku, Tokyo 1138655, Japan

[2] Warukukai Inc Med Inst, Res Ctr Panic Disorder, Tokyo, Japan

[3] Natl Ctr Neurol & Psychiat, Natl Ctr Hosp Mental Nervous & Muscular Disorders, Dept Radiol, Tokyo, Japan

[4] Hlth Sci Univ Hokkaido, Sch Psychol Sci, Sapporo, Hokkaido, Japan

[5] McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada

来源：

NEUROREPORT | 2005年 / 16卷 / 09期

关键词：

amygdala; anticipatory anxiety; fear network; panic attack; panic disorder; positron emission tomography; regional brain glucose metabolism;

D O I：

10.1097/00001756-200506210-00010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study was performed to assess cerebral glucose metabolism in patients with panic disorder using positron emission tomography. F-18-fluorodeoxyglucose positron emission tomography with voxel-based analysis was used to compare regional brain glucose utilization in 12 nonmedicated panic disorder patients, without their experiencing panic attacks during positron emission tomography acquisition, with that in 22 healthy controls. Panic disorder patients showed appreciably high state anxiety before scanning, and exhibited significantly higher levels of glucose uptake in the bilateral amygdala, hippocampus, and thalamus, and in the midbrain, caudal pons, medulla, and cerebellum than controls. These results provided the first functional neuroimaging support in human patients for the neuroanatomical hypothesis of panic disorder focusing on the amygdala-based fear network. NeuroReport 16:927-931 (c) 2005 Lippincott Williams & Wilkins.

引用

页码：927 / 931

页数：5

共 21 条

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