NMDA receptors are involved in dithiothreitol-induced hypothermia

被引：19

作者：

Canini, F ^{[1
]}

Bréjot, T ^{[1
]}

d'Aléo, P ^{[1
]}

Mercier, S ^{[1
]}

Bourdon, L ^{[1
]}

机构：

[1] Serv Sante Armees, Ctr Rech, Dept Facteurs Humains, F-38702 La Tronche, France

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2001年 / 426卷 / 03期

关键词：

dithiothreitol; NMDA receptor; hypothermia; redox;

D O I：

10.1016/S0014-2999(01)01219-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Sulfhydryl-reducing agents, such as dithiothreitol, modulate glutamate N-methyl-D-aspartate (NMDA) receptors. Since these receptors are involved in thermoregulatory processes, we studied the effects of their positive modulation, through a dithiothreitol-induced reduction of the receptor redox site, on thermoregulation in rats maintained at an ambient temperature of 20-22 degreesC. Given intraperitoneally at the dose of 25 and 50 mg . kg(-1), dithiothreitol induced dose-dependent hypothermia. The prior administration of 0.5 mg . kg(-1) of (+/-)-dizocilpine maleate (MK801), a non-competitive glutamate NMDA receptor antagonist, blocked most of the dithiothreitol-induced hypothermia. MK801 given alone was followed by slight transient hyperthermia. This confirms the involvement of NMDA receptors in thermoregulation and suggests that they might be under redox modulation. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：179 / 183

页数：5

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