Treatment of chronic viral hepatitis

被引:23
作者
Main, J [1 ]
McCarron, B [1 ]
Thomas, HC [1 ]
机构
[1] St Marys Hosp, Imperial Coll Sch Med, London W2 1NY, England
关键词
hepatitis B; interferon; hepatitis C;
D O I
10.1177/095632029800900601
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
interferon-alpha therapy has proved effective for up to 40% of patients with adult-acquired chronic hepatitis B virus (HBV) infection and for 20-25% of those with chronic hepatitis C virus (HCV) infection. Nucleoside analogues, such as lamivudine and famciclovir, are showing promise as antiviral agents for chronic HBV and the combination of interferon-alpha and ribavirin is proving to be successful therapy for 40-50% of patients with chronic HCV. In this article we review current therapy and discuss future strategies of the therapy of chronic viral hepatitis.
引用
收藏
页码:449 / 460
页数:12
相关论文
共 112 条
[51]   Age-related response to interferon alfa treatment in women vs men with chronic hepatitis C virus infection [J].
Hayashi, J ;
Kishihara, Y ;
Ueno, K ;
Yamaji, K ;
Kawakami, Y ;
Furusyo, N ;
Sawayama, Y ;
Kashiwagi, S .
ARCHIVES OF INTERNAL MEDICINE, 1998, 158 (02) :177-181
[52]  
Heijtink RA, 1997, J MED VIROL, V53, P282, DOI 10.1002/(SICI)1096-9071(199711)53:3<282::AID-JMV18>3.3.CO
[53]  
2-S
[54]   SERIAL ASSAY OF HEPATITIS-C VIRUS-RNA IN SERUM FOR PREDICTING RESPONSE TO INTERFERON-ALPHA THERAPY [J].
HINO, K ;
OKUDA, M ;
KONISHI, T ;
ISHIKO, H ;
OKITA, K .
DIGESTIVE DISEASES AND SCIENCES, 1995, 40 (01) :14-20
[55]  
Hofgartner WT, 1997, J MED VIROL, V53, P118, DOI 10.1002/(SICI)1096-9071(199710)53:2<118::AID-JMV3>3.0.CO
[56]  
2-C
[57]   Lamivudine resistance in immunocompetent chronic hepatitis B - Incidence and patterns [J].
Honkoop, P ;
Niesters, HGM ;
deMan, RAM ;
Osterhaus, ADME ;
Schalm, SW .
JOURNAL OF HEPATOLOGY, 1997, 26 (06) :1393-1395
[58]  
Honkoop P, 1997, HEPATOLOGY, V26, P211
[59]   TREATMENT OF CHRONIC NON-A,NON-B HEPATITIS WITH RECOMBINANT HUMAN ALPHA-INTERFERON - A PRELIMINARY-REPORT [J].
HOOFNAGLE, JH ;
MULLEN, KD ;
JONES, DB ;
RUSTGI, V ;
DIBISCEGLIE, A ;
PETERS, M ;
WAGGONER, JG ;
PARK, Y ;
JONES, EA .
NEW ENGLAND JOURNAL OF MEDICINE, 1986, 315 (25) :1575-1578
[60]   Characteristics of complete responders to interferon among patients with chronic hepatitis C with high serum levels of RNA [J].
Ide, T ;
Sata, M ;
Suzuki, H ;
Uchimura, Y ;
Shirachi, M ;
Adachi, N ;
Tanikawa, K .
HEPATOLOGY RESEARCH, 1997, 7 (01) :19-27