Alterations of Dendritic Cells in Sepsis: Featured Role in Immunoparalysis

被引：46

作者：

Fan, Xia ^{[1
]}

Liu, Zheng ^{[1
]}

Jin, He ^{[1
]}

Yan, Jun ^{[1
]}

Liang, Hua-ping ^{[1
]}

机构：

[1] Third Mil Med Univ, Daping Hosp, Inst Surg Res, State Key Lab Trauma Burns & Combined Injury, Chongqing 400042, Peoples R China

来源：

BIOMED RESEARCH INTERNATIONAL | 2015年 / 2015卷

关键词：

ACTIVATED-RECEPTOR-GAMMA; CD4(+) T-LYMPHOCYTES; POLYMICROBIAL SEPSIS; INFLAMMATORY RESPONSES; ENDOTOXIN TOLERANCE; PROFOUND DEPLETION; INDUCED IMPAIRMENT; IMMUNE-RESPONSE; C5A RECEPTOR; APOPTOSIS;

D O I：

10.1155/2015/903720

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Sepsis, the leading cause of mortality in intensive care unit, is characterized by hyperinflammatory response in the early stage and followed by a period of immunosuppression. This immune disorder is believed to be the potent factor that is tightly associated with high mortality in sepsis. Dendritic cells (DCs) serve as professional antigen-presenting cells that play a vital role in immune response by activating T lymphocytes. During the progression of sepsis, DCs have been reported to take part in the aberrant immune response and be necessary for survival. Therefore, a better understanding of the DCs pathology will be undoubtedly beneficial for resolving the problems occurring in sepsis. This review discusses effects of sepsis on DCs number and function, including surface molecules expression, cytokines secretion, and T cell activation, and the underlying mechanism as well as some potential therapeutic strategies.

引用

页数：10

共 124 条

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