Increased activation of the caudate nucleus and parahippocampal gyrus in Parkinson's disease patients with dysphagia after repetitive transcranial magnetic stimulation: a case-control study

被引：24

作者：

Huang, Pei-Ling ^{[1
]}

Wang, Song-Jian ^{[2
]}

Sun, Rui-Feng ^{[3
]}

Zhu, Zi-Man ^{[3
]}

Li, Xiao-Ling ^{[3
]}

Li, Wen-Shan ^{[3
]}

Wang, Meng-Yue ^{[2
]}

Lin, Meng ^{[2
]}

Gong, Wei-Jun ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Rehabil Hosp, Dept Neurol Rehabil, Beijing, Peoples R China

[2] Capital Med Univ, Sch Biomed Engn, Beijing Key Lab Fundamental Res Biomech Clin Appl, Beijing, Peoples R China

[3] Capital Med Univ, Beijing Rehabil Med Acad, Dept Neurol Rehabil, Beijing, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2022年 / 17卷 / 05期

关键词：

brain regions; caudate; clinical trial; dysphagia; functional magnetic resonance imaging; parahippocampal gyrus; Parkinson's disease; precentral gyrus; repetitive transcranial magnetic stimulation; saliva swallowing task; DEEP BRAIN-STIMULATION; ADULTS; LIFE;

D O I：

10.4103/1673-5374.324863

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Repetitive transcranial magnetic stimulation (rTMS) has been shown to effectively improve impaired swallowing in Parkinson's disease (PD) patients with dysphagia. However, little is known about how rTMS affects the corresponding brain regions in this patient group. In this casecontrol study, we examined data from 38 PD patients with dysphagia who received treatment at Beijing Rehabilitation Medicine Academy, Capital Medical University. The patients received high-frequency rTMS of the motor cortex once per day for 10 successive days. Changes in brain activation were compared via functional magnetic resonance imaging in PD patients with dysphagia and healthy controls. The results revealed that before treatment, PD patients with dysphagia showed greater activation in the precentral gyrus, supplementary motor area, and cerebellum compared with healthy controls, and this enhanced activation was weakened after treatment. Furthermore, before treatment, PD patients with dysphagia exhibited decreased activation in the parahippocampal gyrus, caudate nucleus, and left thalamus compared with healthy controls, and this activation increased after treatment. In addition, PD patients with dysphagia reported improved subjective swallowing sensations after rTMS. These findings suggest that swallowing function in PD patients with dysphagia improved after rTMS of the motor cortex. This may have been due to enhanced activation of the caudate nucleus and parahippocampal gyrus.

引用

页码：1051 / +

页数：10

共 40 条

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