Tau is central in the genetic Alzheimer-frontotemporal dementia spectrum

被引：44

作者：

Dermaut, B ^{[1
]}

Kumar-Singh, S ^{[1
]}

Rademakers, R ^{[1
]}

Theuns, J ^{[1
]}

Cruts, M ^{[1
]}

Van Broeckhoven, C ^{[1
]}

机构：

[1] Univ Antwerp VIB, Dept Mol Genet, Neurodegenerat Brain Dis Grp, B-2610 Antwerp, Belgium

来源：

TRENDS IN GENETICS | 2005年 / 21卷 / 12期

关键词：

D O I：

10.1016/j.tig.2005.09.005

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In contrast to the common and genetically complex senile form of Alzheimer's disease (AD), the molecular genetic dissection of inherited presenile dementias has given important mechanistic insights into the pathogenesis of degenerative brain disease. Here, we focus on recent genotype-phenotype correlative studies in presenile AD and the frontotemporal dementia (FTD) complex of disorders. Together, these studies suggest that AD and FTD are linked in a genetic spectrum of presenile degenerative brain disorders in which tau appears to be the central player.

引用

页码：664 / 672

页数：9

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