Overcoming inhibitions: subversion of CKI function by viral cyclins

被引：22

作者：

Swanton, C

Card, GL

Mann, D

McDonald, N

Jones, N

机构：

[1] Imperial Canc Res Fund, Gene Regulat Lab, London WC2A 3PX, England

[2] Imperial Canc Res Fund, Struct Biol Lab, London WC2A 3PX, England

[3] Brunel Univ, Dept Biol & Biochem, Uxbridge UB8 3PX, Middx, England

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1999年 / 24卷 / 03期

关键词：

D O I：

10.1016/S0968-0004(99)01354-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA tumour viruses deregulate the mammalian cell cycle to provide a better environment for their replication. Studies of such deregulation have led to the identification of key regulatory steps that normally control the G1-S phase transition of the cell cycle. The balance between the activities of G1-specific cyclin-CDK complexes and their inhibitors is critical. Recent studies suggest that certain herpesviruses disrupt this balance: the viruses encode a cyclin that generates active complexes even in the presence of high inhibitor levels.

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页码：116 / 120

页数：5

相关论文

共 58 条

[31] Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes [J].

Lundberg, AS ;

Weinberg, RA .

MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (02) :753-761

[32] Inactivation of p27(Kip1) by the viral E1A oncoprotein in TGF beta-treated cells [J].

Mal, A ;

Poon, RYC ;

Howe, PH ;

Toyoshima, H ;

Hunter, T ;

Harter, ML .

NATURE, 1996, 380 (6571) :262-265

[33]

MANN DJ, IN PRESS EMBO J

[34] XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage [J].

Masson, M ;

Niedergang, C ;

Schreiber, V ;

Muller, S ;

Menissier-de Murcia, J ;

de Murcia, G .

MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (06) :3563-3571

[35] Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV [J].

Moore, PS ;

Boshoff, C ;

Weiss, RA ;

Chang, Y .

SCIENCE, 1996, 274 (5293) :1739-1744

[36] Cdk2-dependent phosphorylation of p27 facilitates its Myc-induced release from cyclin E/cdk2 complexes [J].

Muller, D ;

Bouchard, C ;

Rudolph, B ;

Steiner, P ;

Stuckmann, I ;

Saffrich, R ;

Ansorge, W ;

Huttner, W ;

Eilers, M .

ONCOGENE, 1997, 15 (21) :2561-2576

[37]

Muller H, 1997, MOL CELL BIOL, V17, P5508

[38]

PAN ZQ, 1993, J BIOL CHEM, V268, P20443

[39] A-TYPE AND B-TYPE CYCLINS DIFFERENTIALLY MODULATE SUBSTRATE-SPECIFICITY OF CYCLIN CDK COMPLEXES [J].

PEEPER, DS ;

PARKER, LL ;

EWEN, ME ;

TOEBES, M ;

HALL, FL ;

XU, M ;

ZANTEMA, A ;

VANDEREB, AJ ;

PIWNICAWORMS, H .

EMBO JOURNAL, 1993, 12 (05) :1947-1954

[40] Expression of cell-cycle regulators p27(Kip1) and cyclin E, alone and in combination, correlate with survival in young breast cancer patients [J].

Porter, PL ;

Malone, KE ;

Heagerty, PJ ;

Alexander, GM ;

Gatti, LA ;

Firpo, EJ ;

Daling, JR ;

Roberts, JM .

NATURE MEDICINE, 1997, 3 (02) :222-225

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