Angiogenesis in nervous system disorders

被引：72

作者：

Zadeh, G

Guha, A

机构：

[1] Univ Toronto, Arthur & Sonia Labatts Brain Tumor Ctr, Hosp Sick Children, Res Inst, Toronto, ON, Canada

[2] Hosp Sick Children, Res Inst, Arthur & Sonia Labatts Brain Tumor Ctr, Toronto, ON M5G 1X8, Canada

[3] Univ Toronto, Toronto Western Hosp, Div Neurosurg, Toronto, ON M5T 2S8, Canada

来源：

NEUROSURGERY | 2003年 / 53卷 / 06期

关键词：

angiogenesis; angiopoietins; antiangiogenic therapy central nervous system; vascular endothelial growth factor; vasculogenesis;

D O I：

10.1227/01.NEU.0000093425.98136.31

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

ANGIOGENESIS IS A crucial requirement for embryonal development and new vessel formation during adult life. Various disease processes such as cancer, ischemia, vascular malformations, and inflammatory processes also depend on pathological angiogenesis. A better understanding of the complex and coordinated interactions among various angiogenic pathways involved in pathological angiogenesis is necessary to improve our therapeutic approaches to the various disease processes observed in the central nervous system. This review summarizes the current understanding of the role of principal angiogenic factors relevant to neurosurgical abnormalities.

引用

页码：1362 / 1374

页数：13

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