Distinguishing possible mechanisms for auxin-mediated developmental control in Arabidopsis: Models with two Aux/IAA and ARF proteins, and two target gene-sets

被引：13

作者：

Bridge, L. J. ^{[1
]}

Mirams, G. R. ^{[3
]}

Kieffer, M. L. ^{[4
]}

King, J. R. ^{[2
]}

Kepinski, S. ^{[4
]}

机构：

[1] Univ Bath, Dept Math Sci, Bath BA2 7AY, Avon, England

[2] Univ Nottingham, Sch Math Sci, Nottingham NG7 2RD, England

[3] Univ Oxford, Dept Physiol Anat & Genet, Oxford OX1 2JD, England

[4] Univ Leeds, Ctr Plant Sci, Leeds LS2 9JT, W Yorkshire, England

来源：

MATHEMATICAL BIOSCIENCES | 2012年 / 235卷 / 01期

基金：

英国生物技术与生命科学研究理事会;

关键词：

Mathematical modelling; Gene regulatory networks; Auxin signalling; Developmental control; Bistability; FEEDBACK LOOPS; NETWORKS;

D O I：

10.1016/j.mbs.2011.10.005

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

New models of gene transcriptional responses to auxin signalling in Arabidopsis are presented. This work extends a previous model of auxin signalling to include networks of gene-sets which may control developmental responses along auxin gradients. Key elements of this new study include models of signalling pathways and networks involving two Aux-IAA proteins (IAAs), auxin response factors (ARFs) and gene targets. Hypotheses for the gene network topologies which may be involved in developmental responses have been tested against experimental observations for root hair growth in particular. In studying these models, we provide a framework for the analysis of auxin signalling with multiple IAAs and ARFs, and discuss the implications of bistability in such systems. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：32 / 44

页数：13

共 18 条

[11] IAA17/AXR3: Biochemical insight into an auxin mutant phenotype [J].

Ouellet, F ;

Overvoorde, PJ ;

Theologis, A .

PLANT CELL, 2001, 13 (04) :829-841

[12] An Auxin Gradient and Maximum in the Arabidopsis Root Apex Shown by High-Resolution Cell-Specific Analysis of IAA Distribution and Synthesis [J].

Petersson, Sara V. ;

Johansson, Annika I. ;

Kowalczyk, Mariusz ;

Makoveychuk, Alexander ;

Wang, Jean Y. ;

Moritz, Thomas ;

Grebe, Markus ;

Benfey, Philip N. ;

Sandberg, Goran ;

Ljung, Karin .

PLANT CELL, 2009, 21 (06) :1659-1668

[13] Comparing different ODE modelling approaches for gene regulatory networks [J].

Polynikis, A. ;

Hogan, S. J. ;

di Bernardo, M. .

JOURNAL OF THEORETICAL BIOLOGY, 2009, 261 (04) :511-530

[14] Modeling transcriptional control in gene networks - Methods, recent results, and future directions [J].

Smolen, P ;

Baxter, DA ;

Byrne, JH .

BULLETIN OF MATHEMATICAL BIOLOGY, 2000, 62 (02) :247-292

[15] Big it up: endoreduplication and cell-size control in plants [J].

Sugimoto-Shirasu, K ;

Roberts, K .

CURRENT OPINION IN PLANT BIOLOGY, 2003, 6 (06) :544-553

[16]

Teale W., 2006, NAT REV MOL CELL BIO, V7

[17] DYNAMICAL BEHAVIOR OF BIOLOGICAL REGULATORY NETWORKS .1. BIOLOGICAL ROLE OF FEEDBACK LOOPS AND PRACTICAL USE OF THE CONCEPT OF THE LOOP-CHARACTERISTIC STATE [J].

THOMAS, R ;

THIEFFRY, D ;

KAUFMAN, M .

BULLETIN OF MATHEMATICAL BIOLOGY, 1995, 57 (02) :247-276

[18] Auxin: A Trigger for Change in Plant Development [J].

Vanneste, Steffen ;

Friml, Jiri .

CELL, 2009, 136 (06) :1005-1016

← 1 2 →