Spontaneous formation of blood-compatible surfaces on hydrophobic polymers: Surface enrichment of a block copolymer with a water-soluble block

被引：46

作者：

Oyane, A

Ishizone, T

Uchida, M

Furukawa, K

Ushida, T

Yokoyama, H

机构：

[1] Natl Inst Adv Ind Sci & Technol, Nanotechnol Res Inst, Tsukuba, Ibaraki 3058565, Japan

[2] Tokyo Inst Technol, Grad Sch Sci & Engn, Meguro Ku, Dept Organ & Polymer Mat, Tokyo 1528552, Japan

[3] Natl Inst Adv Ind Sci & Technol, Inst Human Sci & Biomed Engn, Tsukuba, Ibaraki 3058566, Japan

[4] Univ Tokyo, Grad Sch Engn, Dept Mech Engn, Biomed Engn Lab,Bunkyo Ku, Tokyo 1138656, Japan

来源：

ADVANCED MATERIALS | 2005年 / 17卷 / 19期

关键词：

D O I：

10.1002/adma.200500945

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A polymer surface with excellent blood compatibility has been produced via spontaneous surface segregation of a block copolymer. The water-soluble polymer block (PME3MA) spontaneously segregates into hydrophobic and hydrophilic environments (see Figure), causing the blocks to expel biological substances including proteins, cells and platelets via flexible chain motion.

引用

页码：2329 / +

页数：5

共 15 条

[1] Chemisorbed poly(propylene sulphide)-based copolymers resist biomolecular interactions [J].