Targeting growth factor and cytokine receptors with recombinant peptide libraries

被引:11
作者
Dower, WJ [1 ]
机构
[1] Affymax Res Inst, Palo Alto, CA 92304 USA
关键词
D O I
10.1016/S1367-5931(98)80005-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The single-transmembrane-spanning receptors of cytokines and growth factors have historically proven resistant to the small-molecule screening efforts of the pharmaceutical industry. Advances in combinatorial library approaches to ligand discovery have begun to show success with these targets. There are several recent reports of peptides, derived from randomly assembled collections of L-peptides expressed in recombinant display vectors, that are high-affinity antagonists and even agonists of these receptors. These results indicate that molecules much smaller than the natural protein factors can interact effectively with these receptors, and this may lead the way to the discovery of even smaller nonpeptidic agents.
引用
收藏
页码:328 / 334
页数:7
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