The single-transmembrane-spanning receptors of cytokines and growth factors have historically proven resistant to the small-molecule screening efforts of the pharmaceutical industry. Advances in combinatorial library approaches to ligand discovery have begun to show success with these targets. There are several recent reports of peptides, derived from randomly assembled collections of L-peptides expressed in recombinant display vectors, that are high-affinity antagonists and even agonists of these receptors. These results indicate that molecules much smaller than the natural protein factors can interact effectively with these receptors, and this may lead the way to the discovery of even smaller nonpeptidic agents.
机构:
GENENTECH INC, DEPT PROT ENGN, 460 POINT SAN BRUNO BLVD, S SAN FRANCISCO, CA 94080 USAGENENTECH INC, DEPT PROT ENGN, 460 POINT SAN BRUNO BLVD, S SAN FRANCISCO, CA 94080 USA
CUNNINGHAM, BC
WELLS, JA
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机构:
GENENTECH INC, DEPT PROT ENGN, 460 POINT SAN BRUNO BLVD, S SAN FRANCISCO, CA 94080 USAGENENTECH INC, DEPT PROT ENGN, 460 POINT SAN BRUNO BLVD, S SAN FRANCISCO, CA 94080 USA
机构:
GENENTECH INC, DEPT PROT ENGN, 460 POINT SAN BRUNO BLVD, S SAN FRANCISCO, CA 94080 USAGENENTECH INC, DEPT PROT ENGN, 460 POINT SAN BRUNO BLVD, S SAN FRANCISCO, CA 94080 USA
CUNNINGHAM, BC
WELLS, JA
论文数: 0引用数: 0
h-index: 0
机构:
GENENTECH INC, DEPT PROT ENGN, 460 POINT SAN BRUNO BLVD, S SAN FRANCISCO, CA 94080 USAGENENTECH INC, DEPT PROT ENGN, 460 POINT SAN BRUNO BLVD, S SAN FRANCISCO, CA 94080 USA