Seizure remission in adults with long-standing intractable epilepsy: An extended follow-up

被引：43

作者：

Choi, Hyunmi ^{[1
]}

Heiman, Gary A. ^{[4
]}

Clary, Heidi Munger ^{[1
]}

Etienne, Mill ^{[5
]}

Resor, Stanley R. ^{[1
]}

Hauser, W. Allen ^{[1
,2
,3
]}

机构：

[1] Columbia Univ, Dept Neurol, New York, NY USA

[2] Columbia Univ, Gertrude H Sergievsky Ctr, New York, NY 10027 USA

[3] Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA

[4] Rutgers State Univ, Dept Genet, Piscataway, NJ 08855 USA

[5] Natl Naval Med Ctr, Dept Neurol, Bethesda, MD USA

来源：

EPILEPSY RESEARCH | 2011年 / 93卷 / 2-3期

关键词：

Cohort studies; Natural history studies; Pharmacoresistant epilepsy;

D O I：

10.1016/j.eplepsyres.2010.11.005

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Recent studies have provided much needed data on the probability of seizure remission among adults with chronic intractable epilepsy treated medically. Here we provide an extended follow-up to our earlier study in order to provide a more comprehensive picture of long-term prognosis in this patient population during medical treatment. The prevalence cohort was followed for two outcomes complete seizure remission for >= 12 months and subsequent seizure relapse among those attaining a seizure remission. The study outcomes were estimated using Kaplan-Meier analysis. We found that the probability of attaining a >= 12 months of complete seizure freedom to be approximately 3-4% per year through 8 years of follow-up. By year 5 since the start of seizure remission, the cumulative probability of seizure relapse was 81%, although only half of the patients with seizure relapse went on to experience their previous seizure frequency. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：115 / 119

页数：5

共 9 条

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How long does it take for epilepsy to become intractable? A prospective investigation [J].