Advances in neuropathic pain - Diagnosis, mechanisms, and treatment recommendations

被引：798

作者：

Dworkin, RH ^{[1
]}

Backonja, M ^{[1
]}

Rowbotham, MC ^{[1
]}

Allen, RR ^{[1
]}

Argoff, CR ^{[1
]}

Bennett, GJ ^{[1
]}

Bushnell, MC ^{[1
]}

Farrar, JT ^{[1
]}

Galer, BS ^{[1
]}

Haythornthwaite, JA ^{[1
]}

Hewitt, DJ ^{[1
]}

Loeser, JD ^{[1
]}

Max, MB ^{[1
]}

Saltarelli, M ^{[1
]}

Schmader, KE ^{[1
]}

Stein, C ^{[1
]}

Thompson, D ^{[1
]}

Turk, DC ^{[1
]}

Wallace, MS ^{[1
]}

Watkins, LR ^{[1
]}

Weinstein, SM ^{[1
]}

机构：

[1] Univ Rochester, Sch Med & Dent, Dept Anesthesiol, Rochester, NY 14642 USA

来源：

ARCHIVES OF NEUROLOGY | 2003年 / 60卷 / 11期

关键词：

D O I：

10.1001/archneur.60.11.1524

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Chronic neuropathic pain, caused by lesions in the peripheral or central nervous system, comes in many forms. We describe current approaches to the diagnosis and assessment of neuropathic pain and discuss the results of recent research on its pathophysiologic mechanisms. Randomized controlled clinical trials of gabapentin, the 5% lidocaine patch, opioid analgesics, tramadol hydrochloride, and tricyclic antidepressants provide an evidence-based approach to the treatment of neuropathic pain, and specific recommendations are presented for use of these medications. Continued progress in basic and clinical research on the pathophysiologic mechanisms of neuropathic pain may make it possible to predict effective treatments for individual patients by application of a pain mechanism-based approach.

引用

页码：1524 / 1534

页数：11

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