Effect of selective inhibition of cyclooxygenase 2 on temporary focal cerebral ischemia in rats

被引:46
作者
Hara, K
Kong, DL
Sharp, FR
Weinstein, PR
机构
[1] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Anesthesiol, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA
[4] Vet Affairs Med Ctr, San Francisco, CA 94143 USA
关键词
brain; cyclooxygenase; 2; ischemia; NS-398; prostaglandin E2; rat;
D O I
10.1016/S0304-3940(98)00755-1
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Cyclooxygenase 2 (COX2) is the inducible isoform of COX but its involvement in ischemic neuronal injury is unclear. The effect of selective inhibition of COX2 was evaluated by intraperitoneal administration of NS-398, a selective COX2 inhibitor, before and after 2 h of temporary focal ischemia in rats. After 4 h of reperfusion, the infarct volume and the hemispheric concentration of prostaglandin E2 (PGE2), a major substance produced by COX2, were assessed. The infarct volume was unchanged by NS-398 administration. There was no difference in PGE2 levels between the ischemic and the contralateral hemispheres in the control group. However, PGE2 concentration significantly decreased in the ischemic hemisphere in the NS-398 group. The results are consistent with the previous observation that COX2 is induced in peri-ischemic areas and suggests that COX2 has a significant role in peri-ischemic pathophysiology. (C) 1998 Published by Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:53 / 56
页数:4
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