Hepatitis C Virus Infection Is Blocked by HMGB1 Released from Virus-Infected Cells

被引：62

作者：

Jung, Jong Ha ^{[1
]}

Park, Ji Hoon ^{[1
]}

Jee, Min Hyeok ^{[1
]}

Keum, Sun Ju ^{[1
]}

Cho, Min-Sun ^{[4
]}

Yoon, Seung Kew ^{[5
,6
]}

Jang, Sung Key ^{[1
,2
,3
]}

机构：

[1] Pohang Univ Sci & Technol, Dept Life Sci, PBC, Pohang 790784, Kyungbuk, South Korea

[2] Pohang Univ Sci & Technol, Div Integrat Biosci & Biotechnol, WCU Program, Pohang 790784, Kyungbuk, South Korea

[3] Pohang Univ Sci & Technol, Biotechnol Res Ctr, Pohang 790784, Kyungbuk, South Korea

[4] Ewha Womans Univ, Sch Med, Dept Pathol, Seoul, South Korea

[5] Catholic Univ, Dept Internal Med, Seoul, South Korea

[6] Catholic Univ, WHO Collaborating Ctr Viral Hepatitis, Seoul, South Korea

来源：

JOURNAL OF VIROLOGY | 2011年 / 85卷 / 18期

关键词：

MOBILITY GROUP BOX-1; OXIDATIVE STRESS; PROTEIN; INJURY; HCV; INTERFERON; EXPRESSION; AUTOPHAGY; CIRRHOSIS; BINDING;

D O I：

10.1128/JVI.00682-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

High-mobility group box 1 (HMGB1), an abundant nuclear protein that triggers host immune responses, is an endogenous danger signal involved in the pathogenesis of various infectious agents. However, its role in hepatitis C virus (HCV) infection is not known. Here, we show that HMGB1 protein is translocated from the nucleus to cytoplasm and subsequently is released into the extracellular milieu by HCV infection. Secreted HMGB1 triggers antiviral responses and blocks HCV infection, a mechanism that may limit HCV propagation in HCV patients. Secreted HMGB1 also may have a role in liver cirrhosis, which is a common comorbidity in HCV patients. Further investigations into the roles of HMGB1 in the diseases caused by HCV infection will shed light on and potentially help prevent these serious and prevalent HCV-related diseases.

引用

页码：9359 / 9368

页数：10

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