Kinetics of the immune response during HBV and HCV infection

被引:243
作者
Bertoletti, A [1 ]
Ferrari, C
机构
[1] UCL, Inst Hepatol, Royal Free & Univ Coll London, Sch Med, London WC1E 6HX, England
[2] Azienda Ospedaliera Parma, Div Malattie Infett & Epatol, Parma, Italy
关键词
D O I
10.1053/jhep.2003.50310
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The innate immune system has a role not only in protecting the host during the initial period of virus infection, but also in shaping the nature of the adaptive immune response. In this review, we follow the kinetics of the virologic and immunologic events occurring from the time of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection. We primarily discuss how the early events after infection might influence the development of the adaptive immune response in these 2 important viral infections and how new strategies for more efficient preventive and therapeutic vaccines can be derived from this knowledge.
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页码:4 / 13
页数:10
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共 136 条
[1]   DETECTION OF A NEW ANTIBODY SYSTEM REACTING WITH DANE PARTICLES IN HEPATITIS-B VIRUS-INFECTION [J].
ALBERTI, A ;
DIANA, S ;
SCULARD, GH ;
EDDLESTON, ALW ;
WILLIAMS, R .
BMJ-BRITISH MEDICAL JOURNAL, 1978, 2 (6144) :1056-1058
[2]   Comprehensive determinant mapping of the hepatitis C-specific CD8 cell repertoire reveals unpredicted immune hierarchy [J].
Anthony, DD ;
Valdez, H ;
Post, AB ;
Carlson, NL ;
Heeger, PS ;
Lehmann, PV .
CLINICAL IMMUNOLOGY, 2002, 103 (03) :264-276
[3]   Impaired dendritic cell maturation in patients with chronic, but not resolved, hepatitis C virus infection [J].
Auffermann-Gratzinger, S ;
Keeffe, EB ;
Levy, S .
BLOOD, 2001, 97 (10) :3171-3176
[4]   Impaired allostimulatory function of dendritic cells in chronic hepatitis C infection [J].
Bain, C ;
Fatmi, A ;
Zoulim, F ;
Zarski, JP ;
Trépo, C ;
Inchauspé, G .
GASTROENTEROLOGY, 2001, 120 (02) :512-524
[5]   Immunobiology of dendritic cells [J].
Banchereau, J ;
Briere, F ;
Caux, C ;
Davoust, J ;
Lebecque, S ;
Liu, YT ;
Pulendran, B ;
Palucka, K .
ANNUAL REVIEW OF IMMUNOLOGY, 2000, 18 :767-+
[6]   SELECTIVE KILLING OF HEPATITIS-B ENVELOPE ANTIGEN-SPECIFIC B-CELLS BY CLASS-I-RESTRICTED, EXOGENOUS ANTIGEN-SPECIFIC LYMPHOCYTES-T [J].
BARNABA, V ;
FRANCO, A ;
ALBERTI, A ;
BENVENUTO, R ;
BALSANO, F .
NATURE, 1990, 345 (6272) :258-260
[7]   Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection [J].
Baron, JL ;
Gardiner, L ;
Nishimura, S ;
Shinkai, K ;
Locksley, R ;
Ganem, D .
IMMUNITY, 2002, 16 (04) :583-594
[8]   Protective immune response to hepatitis C virus in chimpanzees rechallenged following clearance of primary infection [J].
Bassett, SE ;
Guerra, B ;
Brasky, K ;
Miskovsky, E ;
Houghton, M ;
Klimpel, GR ;
Lanford, RE .
HEPATOLOGY, 2001, 33 (06) :1479-1487
[9]   Analysis of hepatitis C virus-inoculated chimpanzees reveals unexpected clinical profiles [J].
Bassett, SE ;
Brasky, KM ;
Lanford, RE .
JOURNAL OF VIROLOGY, 1998, 72 (04) :2589-2599
[10]   Reduction in the circulating pDC1/pDC2 ratio and impaired function of ex vivo-generated DC1 in chronic hepatitis B infection [J].
Beckebaum, S ;
Cicinnati, VR ;
Dworacki, G ;
Müller-Berghaus, J ;
Stolz, D ;
Harnaha, J ;
Whiteside, TL ;
Thomson, AW ;
Lu, L ;
Fung, JJ ;
Bonham, CA .
CLINICAL IMMUNOLOGY, 2002, 104 (02) :138-150