Solution- and solid-phase synthesis of radicicol (monorden) and pochonin C

被引：53

作者：

Barluenga, S ^{[1
]}

Moulin, E ^{[1
]}

Lopez, P ^{[1
]}

Winssinger, N ^{[1
]}

机构：

[1] Univ Strasbourg, Inst Sci & Ingn Supramol, Organ & Bioorgan Chem Lab, F-67000 Strasbourg, France

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2005年 / 11卷 / 17期

关键词：

metathesis; natural products; solid-phase synthesis; total synthesis;

D O I：

10.1002/chem.200500160

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A modular synthesis for pochonin C and radicicol is reported. The two natural products were prepared in seven and eight steps, respectively, from three readily available fragments. Alternative syntheses of these compounds were achieved using a combination of polymer-bound reagents and solid phase reactions. The conformation of the two natural products was studied and compared by using 2D NMR spectroscopy.

引用

页码：4935 / 4952

页数：18

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