Microwave-assisted synthesis of poly(ε-caprolactone)poly(ethylene glycol)-poly(ε-caprolactone) tri-block co-polymers and use as matrices for sustained delivery of ibuprofen taken as model drug

被引:23
作者
Yu, ZJ
Liu, LJ [1 ]
机构
[1] Wuhan Univ, Coll Chem & Mol Sci, Dept Polymer Sci, Wuhan 430072, Peoples R China
[2] Wuhan Univ, Minist Euc, Key Lab Biomed Polymers, Wuhan 430072, Peoples R China
基金
中国国家自然科学基金;
关键词
microwave-assisted synthesis; ring-opening polymerization; poly(epsilon-caprolactone); poly(ethylene glycol); ibuprofen; drug controlled release;
D O I
10.1163/1568562054414667
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Poly(epsilon-caprolatone)-poly(ethylene glycol)-poly(epsilon-caprolactone) triblock co-polymers with number-average molar mass ((M) over bar (n)) over 20000 g/mol were prepared by ring-opening polymerization of epsilon-caprolactone initiated by poly(ethylene glycol) under microwave irradiation. This method was proposed as a means to improve in vivo compatibility as no harmful chemicals were involved in the polymerization except e-caprolactone and poly(ethylene glycol). The resulting tri-block copolymers were characterized by FT-IR, H-1-NMR, GPC and WAXD. Their (M) over bar (n) and their composition was controlled by the amount and the chain length of the poly(ethylene glycol) macromers involved in the feed. The ability of poly(epsilon-caprolactone)-poly(ethylene glycol) -poly(epsilon-caprolactone) co-polymers to entrap and deliver drugs was investigated with ibuprofen as a model drug. The release of ibuprofen was significantly influenced by the co-polymer composition and the extent of loading. The in vitro release of ibuprofen was sustained from 3 to 15 days for 10% loading, depending on the ratio of epsilon-caprolactone to ethylene glycol-derived subunits in co-polymer chains. This ratio ranged from 0.97 to 9.78. In the case of the co-polymer whose E-caprolactone molar ratio to ethylene glycol-derived subunits was 2.49, the ibuprofen release was sustained for 2 to 24 days for ibuprofen loads going from 5 to 20 wt%.
引用
收藏
页码:957 / 971
页数:15
相关论文
共 28 条
  • [1] Polycaprolactone-b-poly(ethylene oxide) copolymer micelles as a delivery vehicle for dihydrotestosterone
    Allen, C
    Han, JN
    Yu, YS
    Maysinger, D
    Eisenberg, A
    [J]. JOURNAL OF CONTROLLED RELEASE, 2000, 63 (03) : 275 - 286
  • [2] Photodegradation behavior and mechanism of block copoly(caprolactone-ethylene glycol)
    Bei, JZ
    He, WS
    Hu, XZ
    Wang, SG
    [J]. POLYMER DEGRADATION AND STABILITY, 2000, 67 (02) : 375 - 380
  • [3] Bei JZ, 1997, POLYM ADVAN TECHNOL, V8, P693, DOI 10.1002/(SICI)1099-1581(199711)8:11<693::AID-PAT702>3.0.CO
  • [4] 2-B
  • [5] Synthesis and thermal properties of poly(ethylene glycol)-poly(ε-caprolactone) copolymers
    Bogdanov, B
    Vidts, A
    Van Den Bulcke, A
    Verbeeck, R
    Schacht, E
    [J]. POLYMER, 1998, 39 (8-9) : 1631 - 1636
  • [6] Isothermal crystallization of poly(ε-caprolactone-ethylene glycol) block copolymers
    Bogdanov, B
    Vidts, A
    Schacht, E
    Berghmans, H
    [J]. MACROMOLECULES, 1999, 32 (03) : 726 - 731
  • [7] POLYETHER POLYESTER BLOCK COPOLYMERS BY NON-CATALYZED POLYMERIZATION OF EPSILON-CAPROLACTONE WITH POLY(ETHYLENE GLYCOL)
    CERRAI, P
    TRICOLI, M
    ANDRUZZI, F
    PACI, M
    PACI, M
    [J]. POLYMER, 1989, 30 (02) : 338 - 343
  • [8] Kinetics of the ring-opening polymerization of 6-, 7-, 9-, 12-, 13-, 16-, and 17-membered lactones. Comparison of chemical and enzymatic polymerizations
    Duda, A
    Kowalski, A
    Penczek, S
    Uyama, H
    Kobayashi, S
    [J]. MACROMOLECULES, 2002, 35 (11) : 4266 - 4270
  • [9] Poly(ε-caprolactone) as a potential material for a temporary joint spacer
    Elfick, APD
    [J]. BIOMATERIALS, 2002, 23 (23) : 4463 - 4467
  • [10] LABORATORY SYNTHESIS OF POLYETHYLENE-GLYCOL DERIVATIVES
    HARRIS, JM
    [J]. JOURNAL OF MACROMOLECULAR SCIENCE-REVIEWS IN MACROMOLECULAR CHEMISTRY AND PHYSICS, 1985, C25 (03): : 325 - 373