Prevalent and low-frequency null mutations in the filaggrin gene are associated with early-onset and persistent atopic eczema

被引：85

作者：

Brown, Sara J. ^{[1
,6
]}

Sandilands, Aileen ^{[2
]}

Zhao, Yiwei ^{[2
]}

Liao, Haihui ^{[2
]}

Relton, Caroline L. ^{[3
]}

Meggitt, Simon J. ^{[1
]}

Trembath, Richard C. ^{[4
]}

Barker, Jonathan N. W. N. ^{[5
]}

Reynolds, Nick J. ^{[1
,7
]}

Cordell, Heather J. ^{[6
]}

McLean, W. H. Irwin ^{[2
]}

机构：

[1] Royal Victoria Infirm, Dept Dermatol, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England

[2] Univ Dundee, Ninewells Hosp & Med Sch, Epithelial Genet Grp, Human Genet Unit, Dundee DD1 9SY, Scotland

[3] Newcastle Univ, Sch Clin Med Sci Child Hlth, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[4] Kings Coll London, Dept Med & Mol Genet, London WC2R 2LS, England

[5] Kings Coll London, St Johns Inst Dermatol, London WC2R 2LS, England

[6] Newcastle Univ, Inst Human Genet, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[7] Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2008年 / 128卷 / 06期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/sj.jid.5701206

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 [皮肤病与性病学];

摘要：

引用

页码：1591 / 1594

页数：5

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