Using thymus anatomy to dissect T cell repertoire selection

被引:42
作者
Laufer, TM
Glimcher, LH
Lo, D
机构
[1] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
[2] Scripps Res Inst, Dept Immunol IMM25, La Jolla, CA 92037 USA
关键词
thymus; T lymphocyte; tolerance;
D O I
10.1006/smim.1998.9997
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The thymic development of CD4(+) T cells incorporates the opposing processes of positive and negative selection to produce mature lymphocytes which respond to foreign pep tides in the context of self-major histocompatibility complex class II molecules. Here, we present a model in which these events occur in two temporally and anatomically distinct steps. Mie propose that an initial positive selection step is mediated exclusively by thymic cortical epithelium. Subsequently, all those thymocytes which have been positively selected will interact with medullary epithelium and bone marrow-derived cells. Those thymocytes reacting with excess affinity or avidity to these antigen presenting cells will be negatively selected. Although acknowledging the importance of differential sig-nailing to the developing thymocyte, we will emphasize the centrality of the phenotype of the tissues which comprise the thymus.
引用
收藏
页码:65 / 70
页数:6
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