Key aspects of the novartis compound collection enhancement project for the compilation of a comprehensive chemogenomics drug discovery screening collection

被引：58

作者：

Jacoby, E ^{[1
]}

Schuffenhauer, A ^{[1
]}

Popov, M ^{[1
]}

Azzaoui, K ^{[1
]}

Havill, B ^{[1
]}

Schopfer, U ^{[1
]}

Engeloch, C ^{[1
]}

Stanek, J ^{[1
]}

Acklin, P ^{[1
]}

Rigollier, P ^{[1
]}

Stoll, F ^{[1
]}

Koch, G ^{[1
]}

Meier, P ^{[1
]}

Orain, D ^{[1
]}

Giger, R ^{[1
]}

Hinrichs, J ^{[1
]}

Malagu, K ^{[1
]}

Zimmermann, J ^{[1
]}

Roth, HJ ^{[1
]}

机构：

[1] Novartis Inst BioMed Res, CH-4002 Basel, Switzerland

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2005年 / 5卷 / 04期

关键词：

D O I：

10.2174/1568026053828376

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The NIBR (Novartis Institutes for BioMedical Research) compound collection enrichment and enhancement project integrates corporate internal combinatorial compound synthesis and external compound acquisition activities in order to build up a comprehensive screening collection for a modern drug discovery organization. The main purpose of the screening collection is to supply the Novartis drug discovery pipeline with hit-to-lead compounds for today's and the future's portfolio of drug discovery programs, and to provide toot compounds for the chemogenomics investigation of novel biological pathways and circuits. As such, it integrates designed focused and diversity-based compound sets from the synthetic and natural paradigms able to cope with druggable and currently deemed undruggable targets and molecular interaction modes. Herein, we will summarize together with new trends published in the literature, scientific challenges faced and key approaches taken at NIBR to match the chemical and biological spaces.

引用

页码：397 / 411

页数：15

共 135 条

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