Modern methods to produce natural-product libraries

被引：92

作者：

Abel, U ^{[1
]}

Koch, C ^{[1
]}

Speitling, M ^{[1
]}

Hansske, FG ^{[1
]}

机构：

[1] BioLeads GmbH, D-69123 Heidelberg, Germany

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2002年 / 6卷 / 04期

关键词：

D O I：

10.1016/S1367-5931(02)00338-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Natural sources offer a wealth of chemically diverse compounds that have been evolutionary preselected to modulate biochemical pathways. Several industrial and academic groups are accessing this source using advanced technology platforms. Methods have been reported to generate large and diverse natural-product libraries optimised for high-throughput screening and for a fast discovery process. In addition to prefractionated and pure natural-product libraries, parallel synthesis gives access to synthetic, semi-synthetic and natural-product-like libraries. Natural-product chemistry and organic synthesis are powerful tools for optimising natural leads and for generating new diversity from natural scaffolds. The amalgamation of both may be expected to become an important strategy in future drug design.

引用

页码：453 / 458

页数：6

共 65 条

[1] Combinatorial modification of natural products: Preparation of unencoded and encoded libraries of Rauwolfia alkaloids [J].