Tissue-Resident Memory T Cells

被引：762

作者：

Schenkel, Jason M. ^{[1
,2
]}

Masopust, David ^{[1
,2
]}

机构：

[1] Univ Minnesota, Sch Med, Dept Microbiol, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Ctr Immunol, Sch Med, Minneapolis, MN 55455 USA

来源：

IMMUNITY | 2014年 / 41卷 / 06期

基金：

美国国家卫生研究院;

关键词：

MATURE DENDRITIC CELLS; GROWTH-FACTOR-BETA; CUTTING EDGE; LYMPHOCYTE EGRESS; E-CADHERIN; TGF-BETA; FACTOR-ALPHA; B-CELLS; MIGRATION; VIRUS;

D O I：

10.1016/j.immuni.2014.12.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tissue-resident memory T (Trm) cells constitute a recently identified lymphocyte lineage that occupies tissues without recirculating. They provide a first response against infections reencountered at body surfaces, where they accelerate pathogen clearance. Because Trm cells are not present within peripheral blood, they have not yet been well characterized, but are transcriptionally, phenotypically, and functionally distinct from recirculating central and effector memory T cells. In this review, we will summarize current knowledge of Trm cell ontogeny, regulation, maintenance, and function and will highlight technical considerations for studying this population.

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收藏

页码：886 / 897

页数：12

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