Diabetes, metabolic syndrome, and breast cancer: a review of the current evidence

被引:265
作者
Xue, Fei
Michels, Karin B.
机构
[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Obstet & Gynecol Epidemiol Ctr, Boston, MA USA
[2] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
关键词
breast cancer; type; 2; diabetes; metabolic syndrome; insulin resistance; insulin-like growth factor-I; estrogen; meta-analysis;
D O I
10.1093/ajcn/86.3.823S
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Incidences of breast cancer, type 2 diabetes, and metabolic syndrome have increased over the past decades with the obesity epidemic, especially in industrialized countries. Insulin resistance, hyperinsulinemia, and changes in the signaling of growth hormones and steroid hormones associated with diabetes may affect the risk of breast cancer. We reviewed epidemiologic studies of the association between type 2 diabetes and risk of breast cancer and the available evidence on the role of hormonal mediators of an association between diabetes and breast cancer. The combined evidence supports a modest association between type 2 diabetes and the risk of breast cancer, which appears to be more consistent among postmenopausal than among premenopausal women. Despite many proposed potential pathways, the mechanisms underlying an association between diabetes and breast cancer risk remain unclear, particularly because the 2 diseases share several risk factors, including obesity, a sedentary lifestyle, and possibly intake of saturated fat and refined carbohydrates, that may confound this association. Although the metabolic syndrome is closely related to diabetes and embraces additional components that might influence breast cancer risk, the role of the metabolic syndrome in breast carcinogenesis has not been studied and thus remains unknown.
引用
收藏
页码:823S / 835S
页数:13
相关论文
共 190 条
[71]   Circulating concentrations of insulin-like growth factor-I and risk of breast cancer [J].
Hankinson, SE ;
Willett, WC ;
Colditz, GA ;
Hunter, DJ ;
Michaud, DS ;
Deroo, B ;
Rosner, B ;
Speizer, FE ;
Pollak, M .
LANCET, 1998, 351 (9113) :1393-1396
[72]  
Hankinson Susan E, 2003, Breast Dis, V17, P27
[73]  
HELZLSOUER KJ, 1994, CANCER DETECT PREV, V18, P79
[74]  
HIATT RA, 1982, J NATL CANCER I, V68, P885
[75]  
Hirose Kaoru, 2003, Asian Pac J Cancer Prev, V4, P239
[76]  
Hjalgrim H, 1997, J INTERN MED, V241, P471
[78]   SERUM-LIPIDS AND BREAST-CANCER RISK - A COHORT STUDY OF 5,207 DANISH WOMEN [J].
HOYER, AP ;
ENGHOLM, G .
CANCER CAUSES & CONTROL, 1992, 3 (05) :403-408
[79]   Diet, lifestyle, and the risk of type 2 diabetes mellitus in women. [J].
Hu, FB ;
Manson, JE ;
Stampfer, MJ ;
Colditz, G ;
Liu, S ;
Solomon, CG ;
Willett, WC .
NEW ENGLAND JOURNAL OF MEDICINE, 2001, 345 (11) :790-797
[80]  
Huang Z, 1999, AM J EPIDEMIOL, V150, P1316, DOI 10.1093/oxfordjournals.aje.a009963