The importance of the spleen in malaria

被引：150

作者：

Engwerda, CR

Beattie, L

Amante, FH

机构：

[1] Queensland Inst Med Res, Immunol & Infect Lab, Herston, Qld 4006, Australia

[2] Queensland Inst Med Res, Mol Immunol Lab, Herston, Qld 4006, Australia

[3] Queensland Inst Med Res, Australian Ctr Int & Trop Hlth & Nutr, Herston, Qld 4006, Australia

来源：

TRENDS IN PARASITOLOGY | 2005年 / 21卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/j.pt.2004.11.008

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

There are several malaria vaccine candidates at various stages of development. Many of these target blood stages of Plasmodium falciparum. The spleen is a key site for removal of parasitized red blood cells, generation of immunity and production of new red blood cells during malaria. This article describes how all of these processes are modified following infection, and suggests that until we fully understand how these processes function and are modulated by infection, appropriate malaria vaccine design and delivery will be extremely difficult to achieve.

引用

收藏

页码：75 / 80

页数：6

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