Membrane dynamics, cholesterol homeostasis, and Alzheimer's disease

被引：64

作者：

Chauhan, NB ^{[1
]}

机构：

[1] W Side Vet Adm Med Ctr, Vet Affairs Chicago Hlth Care Syst, Res & Dev, Chicago, IL 60612 USA

[2] Univ Illinois, Dept Neuroanesthesiol, Chicago, IL 60612 USA

来源：

JOURNAL OF LIPID RESEARCH | 2003年 / 44卷 / 11期

关键词：

beta-amyloid precursor; protein processing; lipid raft; caveolae; glycophosphatidylinositol; apolipoprotein E;

D O I：

10.1194/jlr.R300010-JLR200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alzheimer's disease (AD) is characterized by the deposition of beta-amyloid (Abeta) plaques derived from the amyloidogenic processing; of a transmembrane protein called beta-amyloid precursor protein (APP). In addition to the known genetic/sporadic factors that promote the formation of Abeta, the composition and structural dynamics of the membrane are also thought to play a significant role in the amyloidogenic processing of APP that promotes seeding of Abeta.jlr This minireview reinforces the roles played by membrane dynamics, membrane microdomains, and cholesterol homeostasis in relation to amyloidogenesis, and reviews current strategies of lowering cholesterol in treating AD.-N.B. Chauhan. Membrane dynamics, cholesterol homeostasis, and Alzheimer's disease.

引用

页码：2019 / 2029

页数：11

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