Dissolved oxygen from microalgae-gel patch promotes chronic wound healing in diabetes

被引：402

作者：

Chen, Huanhuan ^{[1
,2
]}

Cheng, Yuhao ^{[1
,2
]}

Tian, Jingrun ^{[1
,2
]}

Yang, Peizheng ^{[1
,2
]}

Zhang, Xuerao ^{[1
,2
]}

Chen, Yunhao ^{[1
,2
]}

Hu, Yiqiao ^{[1
,2
,3
]}

Wu, Jinhui ^{[1
,2
,3
,4
]}

机构：

[1] Nanjing Univ, Med Sch, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Peoples R China

[2] Nanjing Univ, Sch Life Sci, Nanjing 210093, Peoples R China

[3] Nanjing Univ, Jiangsu Prov Key Lab Nano Technol, Nanjing 210093, Peoples R China

[4] Nanjing Univ, Chem & Biomed Innovat Ctr, Nanjing 210023, Peoples R China

来源：

SCIENCE ADVANCES | 2020年 / 6卷 / 20期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

HYPERBARIC-OXYGEN; SKIN; HIF-1-ALPHA; EMULSION; THERAPY; HYPOXIA; MICE;

D O I：

10.1126/sciadv.aba4311

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Chronic wounds in diabetes undergo a lifetime risk of developing into diabetic foot ulcers. Oxygen is crucial to wound healing by regulating cell proliferation, migration, and neovascularization. However, current oxygen therapies, including hyperbaric oxygen (HBO) and topical gaseous oxygen (TGO), mainly employ gaseous oxygen delivery, which is much less effective in penetrating the skin. Here, we introduce an oxygen-producing patch, made of living microalgae hydrogel, which can produce dissolved oxygen. The superior performance of the patch that results from its dissolved oxygen delivery is >100-fold much more efficient than TGO penetrating the skin. Further experiments indicate that the patch could promote cell proliferation, migration, and tube formation in vitro, and improve chronic wound healing and the survival of skin grafts in diabetic mice. We believe that the microalgae-gel patch can provide continuous dissolved oxygen to improve chronic wound healing.

引用

页数：10

共 40 条

[1]

[Anonymous], 2017, IDF DIABETES ATLAS

[2]

Stabilization of HIF-1α is critical to improve wound healing in diabetic mice [J].