Dissolved oxygen from microalgae-gel patch promotes chronic wound healing in diabetes

被引：402

作者：

Chen, Huanhuan ^{[1
,2
]}

Cheng, Yuhao ^{[1
,2
]}

Tian, Jingrun ^{[1
,2
]}

Yang, Peizheng ^{[1
,2
]}

Zhang, Xuerao ^{[1
,2
]}

Chen, Yunhao ^{[1
,2
]}

Hu, Yiqiao ^{[1
,2
,3
]}

Wu, Jinhui ^{[1
,2
,3
,4
]}

机构：

[1] Nanjing Univ, Med Sch, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Peoples R China

[2] Nanjing Univ, Sch Life Sci, Nanjing 210093, Peoples R China

[3] Nanjing Univ, Jiangsu Prov Key Lab Nano Technol, Nanjing 210093, Peoples R China

[4] Nanjing Univ, Chem & Biomed Innovat Ctr, Nanjing 210023, Peoples R China

来源：

SCIENCE ADVANCES | 2020年 / 6卷 / 20期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

HYPERBARIC-OXYGEN; SKIN; HIF-1-ALPHA; EMULSION; THERAPY; HYPOXIA; MICE;

D O I：

10.1126/sciadv.aba4311

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Chronic wounds in diabetes undergo a lifetime risk of developing into diabetic foot ulcers. Oxygen is crucial to wound healing by regulating cell proliferation, migration, and neovascularization. However, current oxygen therapies, including hyperbaric oxygen (HBO) and topical gaseous oxygen (TGO), mainly employ gaseous oxygen delivery, which is much less effective in penetrating the skin. Here, we introduce an oxygen-producing patch, made of living microalgae hydrogel, which can produce dissolved oxygen. The superior performance of the patch that results from its dissolved oxygen delivery is >100-fold much more efficient than TGO penetrating the skin. Further experiments indicate that the patch could promote cell proliferation, migration, and tube formation in vitro, and improve chronic wound healing and the survival of skin grafts in diabetic mice. We believe that the microalgae-gel patch can provide continuous dissolved oxygen to improve chronic wound healing.

引用

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页数：10

相关论文

共 40 条

[31]

HIF-1α dysfunction in diabetes [J].

Thangarajah, Hariharan ;

Vial, Ivan N. ;

Grogan, Raymon H. ;

Yao, Dachun ;

Shi, Yubin ;

Januszyk, Michael ;

Galiano, Robert D. ;

Chang, Edward I. ;

Galvez, Michael G. ;

Glotzbach, Jason P. ;

Wong, Victor W. ;

Brownlee, Michael ;

Gurtner, Geoffrey C. .

CELL CYCLE, 2010, 9 (01) :75-79

[32]

The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues [J].

Thangarajah, Hariharan ;

Yao, Dachun ;

Chang, Edward I. ;

Shi, Yubin ;

Jazayeri, Leila ;

Vial, Ivan N. ;

Galiano, Robert D. ;

Du, Xue-Liang ;

Grogan, Raymon ;

Galvez, Michael G. ;

Januszyk, Michael ;

Brownlee, Michael ;

Gurtner, Geoffrey C. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (32) :13505-13510

[33]

Accelerated wound healing in mice by on-site production and delivery of CXCL12 by transformed lactic acid bacteria [J].

Vagesjo, Evelina ;

Ohnstedt, Emelie ;

Mortier, Anneleen ;

Lofton, Hava ;

Huss, Fredrik ;

Proost, Paul ;

Roos, Stefan ;

Phillipson, Mia .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (08) :1895-1900

[34]

FORMATION OF SCAB AND RATE OF EPITHELIZATION OF SUPERFICIAL WOUNDS IN SKIN OF YOUNG DOMESTIC PIG [J].

WINTER, GD .

NATURE, 1962, 193 (4812) :293-&

[35]

HIF-1 is involved in high glucose-induced paracellular permeability of brain endothelial cells [J].

Yan, Jingqi ;

Zhang, Ziyan ;

Shi, Honglian .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2012, 69 (01) :115-128

[36]

Synechococcus elongatus PCC7942 secretes extracellular vesicles to accelerate cutaneous wound healing by promoting angiogenesis [J].

Yin, Hao ;

Chen, Chun-Yuan ;

Liu, Yi-Wei ;

Tan, Yi-Juan ;

Deng, Zhi-Li ;

Yang, Fei ;

Huang, Fei-Yu ;

Wen, Cong ;

Rao, Shan-Shan ;

Luo, Ming-Jie ;

Hu, Xiong-Ke ;

Liu, Zheng-Zhao ;

Wang, Zhen-Xing ;

Cao, Jia ;

Liu, Hao-Ming ;

Liu, Jiang-Hua ;

Yue, Tao ;

Tang, Si-Yuan ;

Xie, Hui .

THERANOSTICS, 2019, 9 (09) :2678-2693

[37]

A dissolved oxygen dressing: A pilot study in an ischemic skin flap model [J].

Zellner, Susan ;

Manabat, Rowena ;

Roe, David F. .

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2015, 43 (01) :93-103

[38]

Triggering of a Dll4-Notch1 loop impairs wound healing in diabetes [J].

Zheng, Xiaowei ;

Narayanan, Sampath ;

Sunkari, Vivekananda Gupta ;

Eliasson, Sofie ;

Botusan, Ileana Ruxandra ;

Grunler, Jacob ;

Catrina, Anca Irinel ;

Radtke, Freddy ;

Xu, Cheng ;

Zhao, Allan ;

Ekberg, Neda Rajamand ;

Lendahl, Urban ;

Catrina, Sergiu-Bogdan .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (14) :6985-6994

[39]

Curcumol Promotes Vascular Endothelial Growth Factor (VEGF)-Mediated Diabetic Wound Healing in Streptozotocin-Induced Hyperglycemic Rats [J].

Zhou, Jie ;

Ni, Maowei ;

Liu, Xia ;

Ren, Zeming ;

Zheng, Zhiguo .

MEDICAL SCIENCE MONITOR, 2017, 23 :555-562

[40]

Roxadustat promotes angiogenesis through HIF-1α/VEGF/VEGFR2 signaling and accelerates cutaneous wound healing in diabetic rats [J].

Zhu, Yu ;

Wang, Yanmao ;

Jia, Yachao ;

Xu, Jia ;

Chai, Yimin .

WOUND REPAIR AND REGENERATION, 2019, 27 (04) :324-334

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