Cross-regulation between the IL-1β/IL-18 processing inflammasome and other inflammatory cytokines

被引：117

作者：

Barker, Brianne R. ^{[2
]}

Taxman, Debra J. ^{[1
,2
]}

Ting, Jenny P-Y ^{[1
,2
]}

机构：

[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2011年 / 23卷 / 05期

关键词：

NF-KAPPA-B; FAMILY-MEMBER NLRC5; SPECK-LIKE PROTEIN; CUTTING EDGE; NLRP3; INFLAMMASOME; INDEPENDENT ROLE; HOST-DEFENSE; CELL-DEATH; DIFFERENTIAL REQUIREMENT; PORPHYROMONAS-GINGIVALIS;

D O I：

10.1016/j.coi.2011.07.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The inflammasome-forming NLRs are well characterized members of a protein complex mediating the activation of caspase-1 and the cleavage of pro-IL-1 beta and pro-IL-18 into their active, secreted forms. New data suggest that components of the inflammasome cascade may have roles in influencing inflammasome-independent pathways of cytokine production. These influences on other immune cytokine pathways are complemented by data suggesting that noninflammasome cytokines can influence the activation of the inflammasome, either directly or by influencing transcription of inflammasome components. The crosstalk between these cytokine cascades may lead to increased abilities for the cell to respond to diverse pathogen threats.

引用

页码：591 / 597

页数：7

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