The prolyl isomerase Pin1 in breast development and cancer

被引：65

作者：

Wulf, G ^{[1
]}

Ryo, A ^{[1
]}

Liou, YC ^{[1
]}

Lu, KP ^{[1
]}

机构：

[1] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med,Dept Med, Canc Biol Program,Div Hematol Oncol, Boston, MA 02215 USA

来源：

BREAST CANCER RESEARCH | 2003年 / 5卷 / 02期

关键词：

breast cancer; breast development; cyclin D1; Pin1; phosphorylation signaling;

D O I：

10.1186/bcr572

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The prolyl isomerase Pin1 specifically isomerizes certain phosphorylated Ser/Thr-Pro bonds and thereby regulates various cellular processes. Pin1 is a target of several oncogenic pathways and is overexpressed in human breast cancer. Its overexpression can lead to upregulation of cyclin D1 and transformation of breast epithelial cells in collaboration with the oncogenic pathways. In contrast, inhibition of Pin1 can suppress the transformation of breast epithelial cells. In addition, Pin1 knockout in mice prevents massive proliferation of breast epithelial cells during pregnancy. Pin1 plays a pivotal role in breast development and may be a promising new anticancer target.

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收藏

页码：76 / 82

页数：7

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