Both early and late cognitive dysfunction affects the electroencephalogram in Parkinson's disease

被引：105

作者：

Caviness, J. N.

Hentz, J. G.

Evidente, V. G.

Driver-Dunckley, E.

Samanta, J.

Mahant, P.

Connor, D. J.

Sabbagh, M. N.

Shill, H. A.

Adler, C. H.

机构：

[1] Mayo Clin, Dept Neurol, Scottsdale, AZ USA

[2] Mayo Clin, Biostat Sect, Scottsdale, AZ USA

[3] Banner Good Samaritan Hlth Ctr, Phoenix, AZ USA

[4] Sun Hlth Res Inst, Sun City, AZ USA

来源：

PARKINSONISM & RELATED DISORDERS | 2007年 / 13卷 / 06期

关键词：

Parkinson's disease; EEG; dementia; mild cognitive impairment;

D O I：

10.1016/j.parkreldis.2007.01.003

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We sought to define quantitative electroencephalographic (EEG) measures as biomarkers of both early and late cognitive decline in Parkinson's disease (PD). PD subjects classified as cognitively normal (PD-CogNL), mild cognitive impairment (PD-MCI), and dementia (PD-D) were studied. Cognitive status and neuropsychological testing was correlated with background rhythm and frequency band EEG power across five frequency bands. We conclude that global EEG measures have potential use as biomarkers in the study of both early and late cognitive deterioration in PD, including for evaluating its treatment. PD-MCI has mean quantitative EEG characteristics that represent an intermediate electrophysiological state between PD-CogNL and PD-D. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：348 / 354

页数：7

共 38 条

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