Catalytic amination of 2-substituted pyridines with hydrazine derivatives

被引：86

作者：

Arterburn, JB ^{[1
]}

Rao, KV ^{[1
]}

Ramdas, R ^{[1
]}

Dible, BR ^{[1
]}

机构：

[1] New Mexico State Univ, Dept Chem & Biochem, Las Cruces, NM 88003 USA

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 09期

关键词：

D O I：

10.1021/ol015731y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Protected pyridylhydrazine derivatives were prepared in a one-step palladium-catalyzed amination reaction using chelating phosphine ligands, 2-Pyridyl chlorides, bromides, and triflates were effective electrophiles in these reactions, Di-tert-butyl hydrazodiformate was an excellent hydrazine substrate, and the resulting products were deprotected under mild conditions. Catalytic amination provides a direct route to protected bifunctional hydrazinopyridine linkers that are suitable for metal-bioconjugate syntheses.

引用

页码：1351 / 1354

页数：4

共 52 条

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