MicroRNAs: a developing story

被引：255

作者：

Pasquinelli, AE ^{[1
]}

Hunter, S ^{[1
]}

Bracht, J ^{[1
]}

机构：

[1] Univ Calif San Diego, Mol Biol Sect, Div Biol 0349, La Jolla, CA 92093 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2005年 / 15卷 / 02期

关键词：

D O I：

10.1016/j.gde.2005.01.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Considering the intense genetic efforts applied to understanding development, it is surprising that a relatively large class of regulatory genes has newly surfaced. The first microRNA gene and its developmental role were described more than ten years ago, but only recently have we fully appreciated the broad and abundant presence of such genes. MicroRNAs are similar to 22 nucleotide RNAs that use antisense complementarity to inhibit expression of specific mRNAs. Recent studies of restricted expression patterns and functional roles have implicated specific microRNAs in complex genetic pathways regulating embryogenesis, hematopoiesis, neuronal differentiation and Hox-mediated development.

引用

页码：200 / 205

页数：6

共 46 条

[31]

Meister G, 2004, MOL CELL, V15, P185, DOI 10.1016/j.molcel.2004.07.007

[32] Microarray analysis of microRNA expression in the developing mammalian brain [J].

Miska, EA ;

Alvarez-Saavedra, E ;

Townsend, M ;

Yoshii, A ;

Sestan, N ;

Rakic, P ;

Constantine-Paton, M ;

Horvitz, HR .

GENOME BIOLOGY, 2004, 5 (09)

[33] miRNP:mRNA association in polyribosomes in a human neuronal cell line [J].

Nelson, PT ;

Hatzigeorgiou, AG ;

Mourelatos, Z .

RNA, 2004, 10 (03) :387-394

[34] Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis [J].

Pillai, RS ;

Artus, CG ;

Filipowicz, W .

RNA, 2004, 10 (10) :1518-1525

[35] Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity [J].

Rand, TA ;

Ginalski, K ;

Grishin, NV ;

Wang, XD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (40) :14385-14389

[36] MicroRNAs in plants [J].

Reinhart, BJ ;

Weinstein, EG ;

Rhoades, MW ;

Bartel, B ;

Bartel, DP .

GENES & DEVELOPMENT, 2002, 16 (13) :1616-1626

[37] Prediction of plant microRNA targets [J].

Rhoades, MW ;

Reinhart, BJ ;

Lim, LP ;

Burge, CB ;

Bartel, B ;

Bartel, DP .

CELL, 2002, 110 (04) :513-520

[38]

Ruvkun Gary, 2004, Cell, VS116, pS93, DOI 10.1016/S0092-8674(04)00034-0

[39] A large imprinted microRNA gene cluster at the mouse Dlkl-Gtl2 domain [J].

Seitz, H ;

Royo, H ;

Bortolin, ML ;

Lin, SP ;

Ferguson-Smith, AC ;

Cavaillé, J .

GENOME RESEARCH, 2004, 14 (09) :1741-1748

[40] Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation [J].

Sempere, LF ;

Freemantle, S ;

Pitha-Rowe, I ;

Moss, E ;

Dmitrovsky, E ;

Ambros, V .

GENOME BIOLOGY, 2004, 5 (03)

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