The anti-parasitic effects of nitric oxide

被引：40

作者：

Ascenzi, P

Bocedi, A

Gradoni, L

机构：

[1] Univ Roma Tre, Dipartimento Biol, I-00146 Rome, Italy

[2] Univ Roma Tre, Lab Interdipartimentale Microscopia Elettron, I-00146 Rome, Italy

[3] Univ Aquila, Dipartimento Chim Ingn Chim & Mat, I-67100 Laquila, Italy

[4] Ist Super Sanita, Lab Parassitol, I-00161 Rome, Italy

来源：

IUBMB LIFE | 2003年 / 55卷 / 10-11期

关键词：

anti-parasitic effects of NO(-donors); nitric oxide; NO-donors; parasitic cysteine protease; enzyme inhibition;

D O I：

10.1080/15216540310001639265

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endogenous and exogenous nitric oxide (NO) possesses antiparasitic effects on both Protozoa and Metazoa. However, NO production requires a tight control to limit cytotoxic damage to the host's own cells. The best known parasitic macromolecular targets for NO(-donors) are cysteine proteases, which are relevant in several aspects of the parasite life cycle and parasite-host relationships, and appear as promising targets for anti-parasitic chemotherapy.

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收藏

页码：573 / 578

页数：6

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