Phylogeny of multidrug transporters

被引：267

作者：

Saier, MH ^{[1
]}

Paulsen, IT

机构：

[1] Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA

[2] Inst Genom Res, Rockville, MD 20850 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2001年 / 12卷 / 03期

关键词：

drugs; transporters; evolution; phylogeny;

D O I：

10.1006/scdb.2000.0246

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We currently recognize five large ubiquitous superfamilies and one small eukaryotic-specific family in which cellular multidrug efflux pumps occur. One, the ABC superfamily, includes members that use ATP hydrolysis to drive drug efflux, but the MFS, RND, MATE and DMT superfamilies include members that are secondary carriers, functioning by drug: H+ or drug: Na+ antiport mechanisms. The small MET family seems to be restricted to endosomal membranes of eukaryotes, and only a single such system has been functionally characterized. In this review article, these families of drug trasnporters are discussed and evaluated from phylogenetic standpoints.

引用

页码：205 / 213

页数：9

共 34 条

[1] Glycopeptide resistance in enterococci
Arthur, M
Reynolds, P
Courvalin, P
[J]. TRENDS IN MICROBIOLOGY, 1996, 4 (10) : 401 - 407
[2] Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii
Bult, CJ
White, O
Olsen, GJ
Zhou, LX
Fleischmann, RD
Sutton, GG
Blake, JA
FitzGerald, LM
Clayton, RA
Gocayne, JD
Kerlavage, AR
Dougherty, BA
Tomb, JF
Adams, MD
Reich, CI
Overbeek, R
Kirkness, EF
Weinstock, KG
Merrick, JM
Glodek, A
Scott, JL
Geoghagen, NSM
Weidman, JF
Fuhrmann, JL
Nguyen, D
Utterback, TR
Kelley, JM
Peterson, JD
Sadow, PW
Hanna, MC
Cotton, MD
Roberts, KM
Hurst, MA
Kaine, BP
Borodovsky, M
Klenk, HP
Fraser, CM
Smith, HO
Woese, CR
Venter, JC
[J]. SCIENCE, 1996, 273 (5278) : 1058 - 1073
[3] A FAMILY OF EXTRACYTOPLASMIC PROTEINS THAT ALLOW TRANSPORT OF LARGE MOLECULES ACROSS THE OUTER MEMBRANES OF GRAM-NEGATIVE BACTERIA
DINH, T
PAULSEN, IT
SAIER, MH
[J]. JOURNAL OF BACTERIOLOGY, 1994, 176 (13) : 3825 - 3831
[4] THE ACT CLUSTER CONTAINS REGULATORY AND ANTIBIOTIC EXPORT GENES, DIRECT TARGETS FOR TRANSLATIONAL CONTROL BY THE BLDA TRANSFER-RNA GENE OF STREPTOMYCES
FERNANDEZMORENO, MA
CABALLERO, JL
HOPWOOD, DA
MALPARTIDA, F
[J]. CELL, 1991, 66 (04) : 769 - 780
[5] WHOLE-GENOME RANDOM SEQUENCING AND ASSEMBLY OF HAEMOPHILUS-INFLUENZAE RD
FLEISCHMANN, RD
ADAMS, MD
WHITE, O
CLAYTON, RA
KIRKNESS, EF
KERLAVAGE, AR
BULT, CJ
TOMB, JF
DOUGHERTY, BA
MERRICK, JM
MCKENNEY, K
SUTTON, G
FITZHUGH, W
FIELDS, C
GOCAYNE, JD
SCOTT, J
SHIRLEY, R
LIU, LI
GLODEK, A
KELLEY, JM
WEIDMAN, JF
PHILLIPS, CA
SPRIGGS, T
HEDBLOM, E
COTTON, MD
UTTERBACK, TR
HANNA, MC
NGUYEN, DT
SAUDEK, DM
BRANDON, RC
FINE, LD
FRITCHMAN, JL
FUHRMANN, JL
GEOGHAGEN, NSM
GNEHM, CL
MCDONALD, LA
SMALL, KV
FRASER, CM
SMITH, HO
VENTER, JC
[J]. SCIENCE, 1995, 269 (5223) : 496 - 512
[6] THE MINIMAL GENE COMPLEMENT OF MYCOPLASMA-GENITALIUM
FRASER, CM
GOCAYNE, JD
WHITE, O
ADAMS, MD
CLAYTON, RA
FLEISCHMANN, RD
BULT, CJ
KERLAVAGE, AR
SUTTON, G
KELLEY, JM
FRITCHMAN, JL
WEIDMAN, JF
SMALL, KV
SANDUSKY, M
FUHRMANN, J
NGUYEN, D
UTTERBACK, TR
SAUDEK, DM
PHILLIPS, CA
MERRICK, JM
TOMB, JF
DOUGHERTY, BA
BOTT, KF
HU, PC
LUCIER, TS
PETERSON, SN
SMITH, HO
HUTCHISON, CA
VENTER, JC
[J]. SCIENCE, 1995, 270 (5235) : 397 - 403
[7] Membrane-fusion protein homologues in Gram-positive bacteria
Harley, KT
Djordjevic, GM
Tseng, TT
Saier, MH
[J]. MOLECULAR MICROBIOLOGY, 2000, 36 (02) : 516 - 517
[8] Harley KT, 2000, J MOL MICROB BIOTECH, V2, P195
[9] JACK DL, 2001, IN PRESS EUR J BIOCH
[10] Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export
Koronakis, V
Sharff, A
Koronakis, E
Luisi, B
Hughes, C
[J]. NATURE, 2000, 405 (6789) : 914 - 919

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