Interrogating the repertoire: broadening the scope of peptide-MHC multimer analysis

被引：89

作者：

Davis, Mark M. ^{[1
,2
]}

Altman, John D. ^{[3
,4
]}

Newell, Evan W. ^{[1
]}

机构：

[1] Stanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA

[2] Stanford Univ, Howard Hughes Med Inst, Sch Med, Stanford, CA 94305 USA

[3] Emory Univ, Emory Vaccine Ctr, Atlanta, GA 30322 USA

[4] Emory Univ, Dept Microbiol & Immunol, Sch Med, Atlanta, GA 30322 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2011年 / 11卷 / 08期

基金：

美国国家卫生研究院;

关键词：

CD8(+) T-CELLS; CLASS-II TETRAMERS; EX-VIVO ANALYSIS; IN-VIVO; ESCHERICHIA-COLI; IMMUNE-RESPONSE; VIRAL-INFECTION; HIGH-AFFINITY; B-CELLS; PRECURSOR FREQUENCIES;

D O I：

10.1038/nri3020

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Labelling antigen-specific T cells with peptide-MHC multimers has provided an invaluable way to monitor T cell-mediated immune responses. A number of recent developments in this technology have made these multimers much easier to make and use in large numbers. Furthermore, enrichment techniques have provided a greatly increased sensitivity that allows the analysis of the naive T cell repertoire directly. Thus, we can expect a flood of new information to emerge in the coming years.

引用

页码：551 / 558

页数：8

共 94 条

[21] Use of baculovirus MHC/peptide display libraries to characterize T-cell receptor ligands [J].

Crawford, F ;

Jordan, KR ;

Stadinski, B ;

Wang, YB ;

Huseby, E ;

Marrack, P ;

Slansky, JE ;

Kappler, JW .

IMMUNOLOGICAL REVIEWS, 2006, 210 :156-170

[22] A population of murine γδ T cells that recognize an inducible MHC class lb molecule [J].

Crowley, MP ;

Fahrer, AM ;

Baumgarth, N ;

Hampl, J ;

Gutgemann, I ;

Teyton, L ;

Chien, YH .

SCIENCE, 2000, 287 (5451) :314-316

[23] Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers [J].

Day, CL ;

Seth, NP ;

Lucas, M ;

Appel, H ;

Gauthier, L ;

Lauer, GM ;

Robbins, GK ;

Szczepiorkowski, ZM ;

Casson, DR ;

Chung, RT ;

Bell, S ;

Harcourt, G ;

Walker, BD ;

Klenerman, P ;

Wucherpfennig, KW .

JOURNAL OF CLINICAL INVESTIGATION, 2003, 112 (06) :831-842

[24] Ara h 1-reactive T cells in individuals with peanut allergy [J].

DeLong, Jonathan H. ;

Simpson, Kelly Hetherington ;

Wambre, Erik ;

James, Eddie A. ;

Robinson, David ;

Kwok, William W. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2011, 127 (05) :1211-U503

[25] Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages [J].

Diefenbach, A ;

Jamieson, AM ;

Liu, SD ;

Shastri, N ;

Raulet, DH .

NATURE IMMUNOLOGY, 2000, 1 (02) :119-126

[26] Enumeration and characterization of virus-specific B cells by multicolor flow cytometry [J].

Doucett, VP ;

Gerhard, W ;

Owler, K ;

Curry, D ;

Brown, L ;

Baumarth, N .

JOURNAL OF IMMUNOLOGICAL METHODS, 2005, 303 (1-2) :40-52

[27] HLA-A2-PEPTIDE COMPLEXES - REFOLDING AND CRYSTALLIZATION OF MOLECULES EXPRESSED IN ESCHERICHIA-COLI AND COMPLEXED WITH SINGLE ANTIGENIC PEPTIDES [J].

GARBOCZI, DN ;

HUNG, DT ;

WILEY, DC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (08) :3429-3433

[28] The CD8 T-Cell Response against Murine Gammaherpesvirus 68 Is Directed toward a Broad Repertoire of Epitopes from both Early and Late Antigens [J].

Gredmark-Russ, Sara ;

Cheung, Evelyn J. ;

Isaacson, Marisa K. ;

Ploegh, Hidde L. ;

Grotenbreg, Gijsbert M. .

JOURNAL OF VIROLOGY, 2008, 82 (24) :12205-12212

[29] Discovery of CD8+ T cell epitopes in Chlamydia trachomatis infection through use of caged class I MHC tetramers [J].

Grotenbreg, Gijsbert M. ;

Roan, Nadia R. ;

Guillen, Eduardo ;

Meijers, Rob ;

Wang, Jia-huai ;

Bell, George W. ;

Starnbach, Michael N. ;

Ploegh, Hidde L. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (10) :3831-3836

[30] Induction of rapid T cell activation and tolerance by systemic presentation of an orally administered antigen [J].

Gütgemann, I ;

Fahrer, AM ;

Altman, JD ;

Davis, MM ;

Chien, YH .

IMMUNITY, 1998, 8 (06) :667-673

← 1 2 3 4 5 6 7 8 9 10 →