One-pot synthesis of 1-alkyl-1H-indazoles from 1,1-dialkylhydrazones via aryne annulation

被引：28

作者：

Markina, Nataliya A. ^{[1
]}

Dubrovskiy, Anton V. ^{[1
]}

Larock, Richard C. ^{[1
]}

机构：

[1] Iowa State Univ, Dept Chem, Ames, IA 50011 USA

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2012年 / 10卷 / 12期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

INDAZOLES; EFFICIENT; CHEMISTRY; FACILE;

D O I：

10.1039/c2ob07117g

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

The reaction of readily accessible 1,1-dialkylhydrazones with commercially available o-(trimethylsilyl) aryl triflates provides a direct one-step route to pharmaceutically important 1-alkylindazoles. The products are obtained in high yields by one-pot NCS-chlorination/aryne annulation or Ac2O-acylation/ deprotection/aromatization protocols.

引用

收藏

页码：2409 / 2412

页数：4

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