Synthesis of o-(Dimethylamino)aryl Ketones and Acridones by the Reaction of 1,1-Dialkylhydrazones and Arynes

被引：30

作者：

Dubrovskiy, Anton V. ^{[1
]}

Larock, Richard C. ^{[1
]}

机构：

[1] Iowa State Univ, Dept Chem, Ames, IA 50011 USA

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 15期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

DERIVATIVES; FUROQUINOLINE; INHIBITORS; ARYLATION; ALKALOIDS; BENZYNE;

D O I：

10.1021/ol2016803

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

A novel, efficient route to biologically and pharmaceutically Important o-(dimethylamino)aryl ketones and acridones has been developed starting from readily available 1,1-dimethylhydrazones of aldehydes and o-(trimethylsilyl)aryl triflates. The reaction proceeds under mild conditions, tolerates a wide range of functional groups, and provides the final products in good to excellent yields.

引用

收藏

页码：4136 / 4139

页数：4

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